Faiz Khunza, Lam Fred C, Chen Jay, Kasper Ekkehard M, Salehi Fateme
Department of Radiology, McMaster University Faculty of Health Sciences, Hamilton, ON, Canada.
Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA, United States.
Front Bioeng Biotechnol. 2022 Jul 6;10:855195. doi: 10.3389/fbioe.2022.855195. eCollection 2022.
Neuroimaging modalities such as computer tomography and magnetic resonance imaging have greatly improved in their ability to achieve higher spatial resolution of neurovascular and soft tissue neuroanatomy, allowing for increased accuracy in the diagnosis of neurological conditions. However, the use of conventional contrast agents that have short tissue retention time and associated renal toxicities, or expensive radioisotope tracers that are not widely available, continue to limit the sensitivity of these imaging modalities. Nanoparticles can potentially address these shortcomings by enhancing tissue retention and improving signal intensity in the brain and neural axis. In this review, we discuss the use of different types of nanotechnology to improve the detection, diagnosis, and treatment of a wide range of neurological diseases.
计算机断层扫描和磁共振成像等神经成像技术在实现更高的神经血管和软组织神经解剖结构空间分辨率方面有了很大改进，提高了神经系统疾病诊断的准确性。然而，传统造影剂组织滞留时间短且伴有肾毒性，或昂贵且难以广泛获取的放射性同位素示踪剂的使用，仍然限制了这些成像技术的灵敏度。纳米颗粒有可能通过增强组织滞留和提高脑及神经轴的信号强度来解决这些缺点。在本综述中，我们讨论了使用不同类型的纳米技术来改善多种神经系统疾病的检测、诊断和治疗。
