Adjemian Jennifer, Frankland Timothy B, Daida Yihe G, Honda Jennifer R, Olivier Kenneth N, Zelazny Adrian, Honda Stacey, Prevots D Rebecca
Emerg Infect Dis. 2017 Mar;23(3):439-447. doi: 10.3201/eid2303.161827.
Previous studies found Hawaiians and Asian-Americans/Pacific Islanders to be independently at increased risk for nontuberculous mycobacterial pulmonary disease (NTMPD) and tuberculosis (TB). To better understand NTM infection and TB risk patterns in Hawaii, USA, we evaluated data on a cohort of patients in Hawaii for 2005-2013. Period prevalence of NTMPD was highest among Japanese, Chinese, and Vietnamese patients (>300/100,000 persons) and lowest among Native Hawaiians and Other Pacific Islanders (50/100,000). Japanese patients were twice as likely as all other racial/ethnic groups to have Mycobacterium abscessus isolated (adjusted odds ratio 2.0, 95% CI 1.2-3.2) but were not at increased risk for infection with other mycobacteria species. In contrast, incidence of TB was stable and was lowest among Japanese patients (no cases) and highest among Filipino, Korean, and Vietnamese patients (>50/100,000). Substantial differences exist in the epidemiology of NTMPD by race/ethnicity, suggesting behavioral and biologic factors that affect disease susceptibility.
以往研究发现，夏威夷人以及亚裔美国人/太平洋岛民患非结核分枝杆菌肺病（NTMPD）和结核病（TB）的风险各自增加。为了更好地了解美国夏威夷的非结核分枝杆菌感染情况和结核病风险模式，我们评估了2005年至2013年夏威夷一组患者的数据。NTMPD的期间患病率在日本、中国和越南患者中最高（>300/10万人口），在夏威夷原住民和其他太平洋岛民中最低（50/10万）。日本患者分离出脓肿分枝杆菌的可能性是所有其他种族/族裔群体的两倍（调整后的优势比为2.0，95%置信区间为1.2 - 3.2），但感染其他分枝杆菌物种的风险并未增加。相比之下，结核病发病率稳定，在日本患者中最低（无病例），在菲律宾、韩国和越南患者中最高（>50/10万）。NTMPD的流行病学在种族/族裔方面存在显著差异，提示存在影响疾病易感性的行为和生物学因素。
