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2020 年中国 G4 基因型欧亚类禽源性 H1N1 猪流感病毒的动物源性威胁。

Zoonotic Threat of G4 Genotype Eurasian Avian-Like Swine Influenza A(H1N1) Viruses, China, 2020.

出版信息

Emerg Infect Dis. 2022 Aug;28(8):1664-1668. doi: 10.3201/eid2808.212530.

DOI:10.3201/eid2808.212530
PMID:35876682
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9328894/
Abstract

We investigated genetic and biologic characteristics of 2 Eurasian avian-like H1N1 swine influenza viruses from pigs in China that belong to the predominant G4 genotype. One swine isolate exhibited strikingly great homology to contemporaneous human Eurasian avian-like H1N1 isolates, preferential binding to the human-type receptor, and vigorous replication in mice without adaptation.

摘要

我们研究了源自中国的两株欧亚类禽流感 H1N1 猪流感病毒的遗传和生物学特征,它们均属于主要的 G4 基因型。一株猪流感分离株与人同期流行的欧亚类禽流感 H1N1 分离株具有惊人的高度同源性,优先结合人源受体,并且无需适应即可在小鼠中大量复制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f807/9328894/6965f17aaa06/21-2530-F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f807/9328894/101ba50d2e7c/21-2530-F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f807/9328894/6965f17aaa06/21-2530-F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f807/9328894/101ba50d2e7c/21-2530-F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f807/9328894/6965f17aaa06/21-2530-F2.jpg

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