Emerg Infect Dis. 2022 Aug;28(8):1664-1668. doi: 10.3201/eid2808.212530.
We investigated genetic and biologic characteristics of 2 Eurasian avian-like H1N1 swine influenza viruses from pigs in China that belong to the predominant G4 genotype. One swine isolate exhibited strikingly great homology to contemporaneous human Eurasian avian-like H1N1 isolates, preferential binding to the human-type receptor, and vigorous replication in mice without adaptation.
我们研究了源自中国的两株欧亚类禽流感 H1N1 猪流感病毒的遗传和生物学特征,它们均属于主要的 G4 基因型。一株猪流感分离株与人同期流行的欧亚类禽流感 H1N1 分离株具有惊人的高度同源性,优先结合人源受体,并且无需适应即可在小鼠中大量复制。