二维纳米纤维和聚己内酯电纺纤维复合支架促进糖尿病创面愈合。
Two-dimensional nanovermiculite and polycaprolactone electrospun fibers composite scaffolds promoting diabetic wound healing.
机构信息
Department of Oral and Cranio-Maxillofacial Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology, No. 639, Zhizaoju Road, 200011, Shanghai, China.
Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
出版信息
J Nanobiotechnology. 2022 Jul 26;20(1):343. doi: 10.1186/s12951-022-01556-w.
BACKGROUND
Promoting diabetic wound healing is still a challenge, and angiogenesis is believed to be essential for diabetic wound healing. Vermiculite is a natural clay material that is very easy to obtain and exhibits excellent properties of releasing bioactive ions, buffering pH, adsorption, and heat insulation. However, there are still many unsolved difficulties in obtaining two-dimensional vermiculite and using it in the biomedical field in a suitable form.
RESULTS
In this study, we present a versatile organic-inorganic composite scaffold, which was constructed by embedding two-dimensional vermiculite nanosheets in polycaprolactone electrospun fibers, for enhancing angiogenesis through activation of the HIF-1α signaling pathway and promoting diabetic wound healing both in vitro and in vivo.
CONCLUSIONS
Together, the rational-designed polycaprolactone electrospun fibers-based composite scaffolds integrated with two-dimensional vermiculite nanosheets could significantly improve neo-vascularization, re-epithelialization, and collagen formation in the diabetic wound bed, thus promoting diabetic wound healing. This study provides a new strategy for constructing bioactive materials for highly efficient diabetic wound healing.
背景
促进糖尿病创面愈合仍然是一个挑战，而血管生成被认为是糖尿病创面愈合的关键。蛭石是一种天然的粘土材料，非常容易获得，具有释放生物活性离子、缓冲 pH 值、吸附和隔热等优异性能。然而，在获得二维蛭石并以合适的形式将其应用于生物医学领域方面，仍存在许多尚未解决的难题。
结果
在本研究中，我们提出了一种多功能的有机-无机复合支架，它是通过将二维蛭石纳米片嵌入聚己内酯电纺纤维中构建而成，通过激活 HIF-1α 信号通路来促进血管生成，并在体外和体内促进糖尿病创面愈合。
结论
综上所述，合理设计的聚己内酯电纺纤维基复合支架与二维蛭石纳米片的整合，可以显著改善糖尿病创面床中的新生血管、再上皮化和胶原形成，从而促进糖尿病创面愈合。本研究为构建高效糖尿病创面愈合的生物活性材料提供了一种新策略。
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