• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

二维纳米纤维和聚己内酯电纺纤维复合支架促进糖尿病创面愈合。

Two-dimensional nanovermiculite and polycaprolactone electrospun fibers composite scaffolds promoting diabetic wound healing.

机构信息

Department of Oral and Cranio-Maxillofacial Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology, No. 639, Zhizaoju Road, 200011, Shanghai, China.

Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.

出版信息

J Nanobiotechnology. 2022 Jul 26;20(1):343. doi: 10.1186/s12951-022-01556-w.

DOI:10.1186/s12951-022-01556-w
PMID:35883146
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9327406/
Abstract

BACKGROUND

Promoting diabetic wound healing is still a challenge, and angiogenesis is believed to be essential for diabetic wound healing. Vermiculite is a natural clay material that is very easy to obtain and exhibits excellent properties of releasing bioactive ions, buffering pH, adsorption, and heat insulation. However, there are still many unsolved difficulties in obtaining two-dimensional vermiculite and using it in the biomedical field in a suitable form.

RESULTS

In this study, we present a versatile organic-inorganic composite scaffold, which was constructed by embedding two-dimensional vermiculite nanosheets in polycaprolactone electrospun fibers, for enhancing angiogenesis through activation of the HIF-1α signaling pathway and promoting diabetic wound healing both in vitro and in vivo.

CONCLUSIONS

Together, the rational-designed polycaprolactone electrospun fibers-based composite scaffolds integrated with two-dimensional vermiculite nanosheets could significantly improve neo-vascularization, re-epithelialization, and collagen formation in the diabetic wound bed, thus promoting diabetic wound healing. This study provides a new strategy for constructing bioactive materials for highly efficient diabetic wound healing.

摘要

背景

促进糖尿病创面愈合仍然是一个挑战，而血管生成被认为是糖尿病创面愈合的关键。蛭石是一种天然的粘土材料，非常容易获得，具有释放生物活性离子、缓冲 pH 值、吸附和隔热等优异性能。然而，在获得二维蛭石并以合适的形式将其应用于生物医学领域方面，仍存在许多尚未解决的难题。

结果

在本研究中，我们提出了一种多功能的有机-无机复合支架，它是通过将二维蛭石纳米片嵌入聚己内酯电纺纤维中构建而成，通过激活 HIF-1α 信号通路来促进血管生成，并在体外和体内促进糖尿病创面愈合。

结论

综上所述，合理设计的聚己内酯电纺纤维基复合支架与二维蛭石纳米片的整合，可以显著改善糖尿病创面床中的新生血管、再上皮化和胶原形成，从而促进糖尿病创面愈合。本研究为构建高效糖尿病创面愈合的生物活性材料提供了一种新策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9435/9327406/2d8d0a6e235f/12951_2022_1556_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9435/9327406/5048f225207c/12951_2022_1556_Sch1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9435/9327406/88315d97f468/12951_2022_1556_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9435/9327406/860dd4a9de58/12951_2022_1556_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9435/9327406/50b908d8fe6b/12951_2022_1556_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9435/9327406/cec11df5fb22/12951_2022_1556_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9435/9327406/07dac06dc054/12951_2022_1556_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9435/9327406/c928fc6ea8a6/12951_2022_1556_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9435/9327406/2d8d0a6e235f/12951_2022_1556_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9435/9327406/5048f225207c/12951_2022_1556_Sch1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9435/9327406/88315d97f468/12951_2022_1556_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9435/9327406/860dd4a9de58/12951_2022_1556_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9435/9327406/50b908d8fe6b/12951_2022_1556_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9435/9327406/cec11df5fb22/12951_2022_1556_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9435/9327406/07dac06dc054/12951_2022_1556_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9435/9327406/c928fc6ea8a6/12951_2022_1556_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9435/9327406/2d8d0a6e235f/12951_2022_1556_Fig7_HTML.jpg

相似文献

1
Two-dimensional nanovermiculite and polycaprolactone electrospun fibers composite scaffolds promoting diabetic wound healing.二维纳米纤维和聚己内酯电纺纤维复合支架促进糖尿病创面愈合。
J Nanobiotechnology. 2022 Jul 26;20(1):343. doi: 10.1186/s12951-022-01556-w.
2
An aligned porous electrospun fibrous membrane with controlled drug delivery - An efficient strategy to accelerate diabetic wound healing with improved angiogenesis.一种具有药物控制释放功能的取向多孔静电纺丝纤维膜 - 一种促进糖尿病伤口愈合和改善血管生成的有效策略。
Acta Biomater. 2018 Apr 1;70:140-153. doi: 10.1016/j.actbio.2018.02.010. Epub 2018 Feb 15.
3
A conducive bioceramic/polymer composite biomaterial for diabetic wound healing.一种用于糖尿病伤口愈合的具有促进作用的生物陶瓷/聚合物复合生物材料。
Acta Biomater. 2017 Sep 15;60:128-143. doi: 10.1016/j.actbio.2017.07.020. Epub 2017 Jul 14.
4
Highly efficient local delivery of endothelial progenitor cells significantly potentiates angiogenesis and full-thickness wound healing.高效的内皮祖细胞局部递送显著增强血管生成和全层创面愈合。
Acta Biomater. 2018 Mar 15;69:156-169. doi: 10.1016/j.actbio.2018.01.019. Epub 2018 Feb 1.
5
Bioactive antibacterial silica-based nanocomposites hydrogel scaffolds with high angiogenesis for promoting diabetic wound healing and skin repair.具有高血管生成能力的生物活性抗菌硅基纳米复合材料水凝胶支架，促进糖尿病创面愈合和皮肤修复。
Theranostics. 2020 Mar 31;10(11):4929-4943. doi: 10.7150/thno.41839. eCollection 2020.
6
An aligned porous electrospun fibrous scaffold with embedded asiatic acid for accelerating diabetic wound healing.一种具有取向多孔结构的静电纺丝纤维支架，其中嵌入了积雪草酸，可加速糖尿病创面愈合。
J Mater Chem B. 2019 Oct 16;7(40):6125-6138. doi: 10.1039/c9tb01327j.
7
Copper and cobalt doped bioactive glass-fish dermal collagen electrospun mat triggers key events of diabetic wound healing in full-thickness skin defect model.铜钴掺杂生物活性玻璃-鱼皮胶原蛋白电纺垫在全层皮肤缺损模型中引发糖尿病伤口愈合的关键事件。
J Mech Behav Biomed Mater. 2022 Oct;134:105414. doi: 10.1016/j.jmbbm.2022.105414. Epub 2022 Aug 12.
8
Efficient Angiogenesis-Based Diabetic Wound Healing/Skin Reconstruction through Bioactive Antibacterial Adhesive Ultraviolet Shielding Nanodressing with Exosome Release.高效血管生成的糖尿病创面愈合/皮肤重建：基于具有外泌体释放功能的生物活性抗菌黏附型紫外屏蔽纳米敷料。
ACS Nano. 2019 Sep 24;13(9):10279-10293. doi: 10.1021/acsnano.9b03656. Epub 2019 Sep 9.
9
Controlled release of lawsone from polycaprolactone/gelatin electrospun nano fibers for skin tissue regeneration.聚己内酯/明胶电纺纳米纤维中花色苷的控释及其用于皮肤组织再生。
Int J Biol Macromol. 2019 Mar 1;124:478-491. doi: 10.1016/j.ijbiomac.2018.11.237. Epub 2018 Nov 27.
10
An electrospun scaffold integrating nucleic acid delivery for treatment of full-thickness wounds.电纺支架整合核酸递送治疗全层创面。
Biomaterials. 2013 May;34(15):3891-901. doi: 10.1016/j.biomaterials.2013.02.016. Epub 2013 Feb 27.

引用本文的文献

1
Electrospinning in promoting chronic wound healing: materials, process, and applications.静电纺丝在促进慢性伤口愈合中的应用：材料、工艺及应用
Front Bioeng Biotechnol. 2025 Mar 6;13:1550553. doi: 10.3389/fbioe.2025.1550553. eCollection 2025.
2
Enhancing diabetic wound healing: advances in electrospun scaffolds from pathogenesis to therapeutic applications.促进糖尿病伤口愈合：从发病机制到治疗应用的电纺支架研究进展
Front Bioeng Biotechnol. 2024 Feb 5;12:1354286. doi: 10.3389/fbioe.2024.1354286. eCollection 2024.
3
Mechanism of damage of HIF-1 signaling in chronic diabetic foot ulcers and its related therapeutic perspectives.

本文引用的文献

1
Cysteine-rich domain of type III collagen N-propeptide inhibits fibroblast activation by attenuating TGFβ signaling.III 型胶原 N 端前肽富含半胱氨酸结构域通过抑制 TGFβ 信号转导抑制成纤维细胞活化。
Matrix Biol. 2022 May;109:19-33. doi: 10.1016/j.matbio.2022.03.004. Epub 2022 Mar 24.
2
Efficient removal of mefenamic acid and ibuprofen on organo-Vts with a quinoline-containing gemini surfactant: Adsorption studies and model calculations.含喹啉的Gemini 型表面活性剂有机 Vts 对甲芬那酸和布洛芬的高效去除：吸附研究和模型计算。
Chemosphere. 2022 May;295:133846. doi: 10.1016/j.chemosphere.2022.133846. Epub 2022 Feb 1.
3
慢性糖尿病足溃疡中HIF-1信号通路的损伤机制及其相关治疗前景
Heliyon. 2024 Jan 24;10(3):e24656. doi: 10.1016/j.heliyon.2024.e24656. eCollection 2024 Feb 15.
4
Sprayed PAA-CaO nanoparticles combined with calcium ions and reactive oxygen species for antibacterial and wound healing.喷雾状的聚（丙烯酸）-氧化钙纳米颗粒联合钙离子与活性氧用于抗菌和伤口愈合。
Regen Biomater. 2023 Aug 21;10:rbad071. doi: 10.1093/rb/rbad071. eCollection 2023.
5
MXene-Embedded Electrospun Polymeric Nanofibers for Biomedical Applications: Recent Advances.用于生物医学应用的MXene嵌入电纺聚合物纳米纤维：最新进展
Micromachines (Basel). 2023 Jul 23;14(7):1477. doi: 10.3390/mi14071477.
6
Therapeutic Efficacy of Polymeric Biomaterials in Treating Diabetic Wounds-An Upcoming Wound Healing Technology.聚合物生物材料在治疗糖尿病伤口中的治疗效果——一种即将出现的伤口愈合技术。
Polymers (Basel). 2023 Feb 27;15(5):1205. doi: 10.3390/polym15051205.
7
Effect of composite biodegradable biomaterials on wound healing in diabetes.复合可生物降解生物材料对糖尿病伤口愈合的影响。
Front Bioeng Biotechnol. 2022 Nov 25;10:1060026. doi: 10.3389/fbioe.2022.1060026. eCollection 2022.
Sprayable β-FeSi composite hydrogel for portable skin tumor treatment and wound healing.
可喷涂的β-FeSi 复合水凝胶用于便携皮肤肿瘤治疗和伤口愈合。
Biomaterials. 2021 Dec;279:121225. doi: 10.1016/j.biomaterials.2021.121225. Epub 2021 Oct 28.
4
Topical gel-based biomaterials for the treatment of diabetic foot ulcers.基于凝胶的局部生物材料治疗糖尿病足溃疡。
Acta Biomater. 2022 Jan 15;138:73-91. doi: 10.1016/j.actbio.2021.10.045. Epub 2021 Oct 30.
5
Photothermal nanofibres enable safe engineering of therapeutic cells.光热纳米纤维能够安全地实现治疗细胞的工程改造。
Nat Nanotechnol. 2021 Nov;16(11):1281-1291. doi: 10.1038/s41565-021-00976-3. Epub 2021 Oct 21.
6
Electrospun PCL/MoS Nanofiber Membranes Combined with NIR-Triggered Photothermal Therapy to Accelerate Bone Regeneration.静电纺丝 PCL/MoS 纳米纤维膜联合近红外触发光热疗法加速骨再生。
Small. 2021 Dec;17(51):e2104747. doi: 10.1002/smll.202104747. Epub 2021 Oct 13.
7
Hemostatic Electrospun Nanocomposite Containing Poly(lactic acid)/Halloysite Nanotube Functionalized by Poly(amidoamine) Dendrimer for Wound Healing Application: In Vitro and In Vivo Assays.含聚乳酸/海泡石纳米管的止血电纺纳米复合材料的制备及其在创伤愈合中的应用：体外和体内评价。
Macromol Biosci. 2022 Jan;22(1):e2100313. doi: 10.1002/mabi.202100313. Epub 2021 Oct 29.
8
Ubiquitination Flow Repressors: Enhancing Wound Healing of Infectious Diabetic Ulcers through Stabilization of Polyubiquitinated Hypoxia-Inducible Factor-1α by Theranostic Nitric Oxide Nanogenerators.泛素化流抑制剂：通过治疗性一氧化氮纳米发电机稳定多泛素化缺氧诱导因子-1α增强感染性糖尿病溃疡的愈合。
Adv Mater. 2021 Nov;33(45):e2103593. doi: 10.1002/adma.202103593. Epub 2021 Sep 23.
9
Sustained oxygenation accelerates diabetic wound healing by promoting epithelialization and angiogenesis and decreasing inflammation.持续的氧合作用通过促进上皮化和血管生成以及减少炎症来加速糖尿病伤口愈合。
Sci Adv. 2021 Aug 27;7(35). doi: 10.1126/sciadv.abj0153. Print 2021 Aug.
10
Functional Hydrogels as Wound Dressing to Enhance Wound Healing.功能性水凝胶作为伤口敷料以促进伤口愈合。
ACS Nano. 2021 Aug 24;15(8):12687-12722. doi: 10.1021/acsnano.1c04206. Epub 2021 Aug 10.