Masimen Mohammad Asyraf Adhwa, Harun Noor Aniza, Maulidiani M, Ismail Wan Iryani Wan
Cell Signalling and Biotechnology Research Group (CeSBTech), Faculty of Science and Marine Environment, Universiti Malaysia Terengganu, Kuala Nerus 21030, Terengganu, Malaysia.
Advanced NanoMaterials (ANOMA) Research Group, Faculty of Science and Marine Environment, Universiti Malaysia Terengganu, Kuala Nerus 21030, Terengganu, Malaysia.
Antibiotics (Basel). 2022 Jul 15;11(7):951. doi: 10.3390/antibiotics11070951.
Antibiotics are regarded as a miracle in the medical field as it prevents disease caused by pathogenic bacteria. Since the discovery of penicillin, antibiotics have become the foundation for modern medical discoveries. However, bacteria soon became resistant to antibiotics, which puts a burden on the healthcare system. Methicillin-resistant (MRSA) has become one of the most prominent antibiotic-resistant bacteria in the world since 1961. MRSA primarily developed resistance to beta-lactamases antibiotics and can be easily spread in the healthcare system. Thus, alternatives to combat MRSA are urgently required. Antimicrobial peptides (AMPs), an innate host immune agent and silver nanoparticles (AgNPs), are gaining interest as alternative treatments against MRSA. Both agents have broad-spectrum properties which are suitable candidates for controlling MRSA. Although both agents can exhibit antimicrobial effects independently, the combination of both can be synergistic and complementary to each other to exhibit stronger antimicrobial activity. The combination of AMPs and AgNPs also reduces their own weaknesses as their own, which can be developed as a potential agent to combat antibiotic resistance especially towards MRSA. Thus, this review aims to discuss the potential of antimicrobial peptides and silver nanoparticles towards controlling MRSA pathogen growth.
抗生素在医学领域被视为一项奇迹，因为它能预防由病原菌引起的疾病。自青霉素被发现以来，抗生素已成为现代医学发现的基础。然而，细菌很快就对抗生素产生了耐药性，这给医疗系统带来了负担。自1961年以来，耐甲氧西林金黄色葡萄球菌（MRSA）已成为世界上最突出的耐药细菌之一。MRSA主要对β-内酰胺类抗生素产生耐药性，并且很容易在医疗系统中传播。因此，迫切需要对抗MRSA的替代方法。抗菌肽（AMPs），一种先天性宿主免疫剂和银纳米颗粒（AgNPs），作为对抗MRSA的替代治疗方法正受到关注。这两种制剂都具有广谱特性，是控制MRSA的合适候选物。虽然这两种制剂都能独立发挥抗菌作用，但两者的组合可能具有协同作用且相互补充，从而表现出更强的抗菌活性。AMPs和AgNPs的组合还弥补了它们自身的弱点，可被开发成为一种对抗抗生素耐药性尤其是针对MRSA的潜在制剂。因此，本综述旨在探讨抗菌肽和银纳米颗粒在控制MRSA病原体生长方面的潜力。
