Brambati B, Oldrini A, Ferrazzi E, Lanzani A
Prenat Diagn. 1987 Mar;7(3):157-69. doi: 10.1002/pd.1970070303.
Chorionic villus sampling was performed between 7 and 12 weeks gestation in 1,000 patients, 935 of whom intended to continue after fetal diagnosis. Transcervical and Transabdominal aspiration techniques were used providing a sampling success rate of 99 per cent. Anatomical and clinical contraindications to transcervical aspiration were pointed out, and the complementary role of the transabdominal approach evaluated. In the 615 concluded pregnancies an overall abortion rate of 4.1 per cent was observed. A significant association between fetal loss and number of catheter insertions was demonstrated. Bacterial inoculation by catheter insertion and colonization of uterine cavity was suspected as the cause of chorionamnionitis diagnosed in two cases (0.2 per cent) after CVS. Bleeding was the most frequent early complication (12.0 per cent) following chorionic aspiration, but was not significantly related to pregnancy wastage. Late complications, i.e. premature rupture of membranes (0.8 per cent), preterm delivery (6.3 per cent), perinatal losses (1.2 per cent), placental disorders (1.6 per cent), and congenital defects (2.6 per cent) did not exceed the expected values. Normal intrauterine growth patterns were ultrasonically estimated by cross-sectional and longitudinal studies, while the weight at birth was normally distributed in the range of the general population.
对1000例妊娠7至12周的患者进行了绒毛取样，其中935例患者在胎儿诊断后打算继续妊娠。采用经宫颈和经腹抽吸技术，取样成功率为99%。指出了经宫颈抽吸的解剖学和临床禁忌证，并评估了经腹途径的辅助作用。在615例已结束的妊娠中，观察到总体流产率为4.1%。胎儿丢失与导管插入次数之间存在显著关联。怀疑经导管插入的细菌接种和子宫腔定植是绒毛取样术后两例（0.2%）诊断为绒毛膜羊膜炎的原因。出血是绒毛取样后最常见的早期并发症（12.0%），但与妊娠丢失无显著相关性。晚期并发症，即胎膜早破（0.8%）、早产（6.3%）、围产期丢失（1.2%）、胎盘疾病（1.6%）和先天性缺陷（2.6%）均未超过预期值。通过横断面和纵向研究超声评估了正常的宫内生长模式，而出生体重在一般人群范围内呈正态分布。
