Department of Outpatient Therapy and General Practice with Course of Postgraduate Education, V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, 660022 Krasnoyarsk, Russia.
Department of Therapy, Faculty of Postgraduate Education, Chita State Medical Academy, 672000 Chita, Russia.
Genes (Basel). 2022 Jul 12;13(7):1234. doi: 10.3390/genes13071234.
This work is a review of preclinical and clinical studies of the role of telomeres and telomerase in the development and progression of coronary heart disease (CHD).
A search for full-text publications (articles, reviews, meta-analyses, Cochrane reviews, and clinical cases) in English and Russian was carried out in the databases PubMed, Oxford University Press, Scopus, Web of Science, Springer, and E-library electronic library using keywords and their combinations. The search depth is 11 years (2010-2021).
The review suggests that the relative leukocyte telomere length (LTL) is associated with the development of socially significant and widespread cardiovascular diseases such as CHD and essential hypertension. At the same time, the interests of researchers are mainly focused on the study of the relative LTL in CHD.
Despite the scientific and clinical significance of the analyzed studies of the relative length of human LTL as a biological marker of cardiovascular diseases, their implementation in real clinical practice is difficult due to differences in the design and methodology of the analyzed studies, as well as differences in the samples by gender, age, race, and ethnicity. The authors believe that clinical studies of the role of the relative length of leukocyte telomeres in adult patients with coronary heart disease are the most promising and require large multicenter studies with a unified design and methodology.
本研究综述了端粒和端粒酶在冠心病（CHD）发展和进展中的作用的临床前和临床研究。
在 PubMed、牛津大学出版社、Scopus、Web of Science、Springer 和 E-library 电子图书馆中，使用关键词及其组合，以英文和俄文对全文出版物（文章、综述、荟萃分析、Cochrane 综述和临床病例）进行检索。搜索深度为 11 年（2010-2021 年）。
综述表明，相对白细胞端粒长度（LTL）与社会意义重大且广泛的心血管疾病如 CHD 和原发性高血压的发展有关。同时，研究人员的兴趣主要集中在研究 CHD 中相对 LTL 上。
尽管分析的相对人类 LTL 长度作为心血管疾病生物标志物的研究具有科学和临床意义，但由于分析研究的设计和方法学以及按性别、年龄、种族和民族划分的样本存在差异，其在实际临床实践中的实施存在困难。作者认为，成年冠心病患者白细胞端粒相对长度的作用的临床研究最具前景，需要进行具有统一设计和方法学的大型多中心研究。
