Department of Anatomy and Neuroscience, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, Croatia.
Department of Anatomy, Histology, Embryology, Pathological Anatomy and Pathological Histology, Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, Croatia.
Medicina (Kaunas). 2022 Jun 26;58(7):854. doi: 10.3390/medicina58070854.
A high-fat diet causes inflammation in the organism and many metabolic disorders. Adipose tissue secretes adipokines that affect the function of many organs. The health status of the mother before and during pregnancy affects the health of the offspring. The aim of this study was to determine how the type of maternal diet and the change in the type of diet in the offspring affects the histological characteristics of the ovaries and subcutaneous and perigonadal adipose tissue in female rat offspring. Ten female rats were divided into two groups. One group was fed standard laboratory chow, and the other was fed a high-fat diet and mated with a male of the same breed. The offspring of both groups of dams were divided into four subgroups with different feeding protocols. At 22 weeks of age, the offspring were sacrificed. Ovaries and subcutaneous and perigonadal adipose tissue were isolated. In the ovaries, the presence of cystic formations was investigated. Histomorphometric analysis was performed in two types of adipose tissue. The weight of the ovaries of the offspring of mothers fed a high-fat diet was significantly higher than that of the offspring of mothers fed standard laboratory diets. Cystic formations were found in the ovaries of the offspring of mothers fed a high-fat diet. In subcutaneous adipose tissue, the percentage of small-sized adipocytes was significantly higher in the offspring of mothers fed standard laboratory diets. There were no significant differences in adipocyte surface area and adipocyte number between groups. Maternal diet influences the morphology of the ovaries and adipose tissue of the offspring.
高脂肪饮食会导致机体炎症和许多代谢紊乱。脂肪组织分泌脂联素，影响许多器官的功能。母亲在怀孕前后的健康状况会影响后代的健康。本研究的目的是确定母体饮食的类型以及后代饮食类型的变化如何影响雌性大鼠后代的卵巢和皮下及卵巢旁脂肪组织的组织学特征。
将 10 只雌性大鼠分为两组。一组喂食标准实验室饲料，另一组喂食高脂肪饮食并与同品种雄性交配。两组母鼠的后代分为四个具有不同喂养方案的亚组。在 22 周龄时，处死后代。分离卵巢和皮下及卵巢旁脂肪组织。在卵巢中，研究了囊性形成的存在。对两种脂肪组织进行了组织形态计量学分析。
喂食高脂肪饮食的母鼠后代的卵巢重量明显高于喂食标准实验室饮食的母鼠后代。喂食高脂肪饮食的母鼠后代的卵巢中发现了囊性形成。在皮下脂肪组织中，喂食标准实验室饮食的母鼠后代中小体型脂肪细胞的百分比明显更高。各组间脂肪细胞表面积和脂肪细胞数量无显著差异。
母体饮食会影响后代的卵巢和脂肪组织形态。
