Mazeaud Simon, Castellana Fabio, Coelho-Junior Hélio José, Panza Francesco, Rondanelli Mariangela, Fassio Federico, De Pergola Giovanni, Zupo Roberta, Sardone Rodolfo
UFR of Biology, Campus Universitaire des Cézeaux, University of Clermont Auvergne (UCA), 63000 Clermont-Ferrand, France.
Unit of Data Sciences and Technology Innovation for Population Health, Department of Basic Medicine, National Institute of Gastroenterology "Saverio de Bellis", Research Hospital, 70013 Castellana Grotte, Italy.
Metabolites. 2022 Jul 15;12(7):654. doi: 10.3390/metabo12070654.
Declining physical functioning covers a prominent span of later life and, as a modifiable driver to be leveraged, lifestyle plays a critical role. This research aimed to undertake a systematic review investigating the association between levels of coffee consumption and declining conditions of physical functioning during aging, such as sarcopenia, frailty, weakness, falls, and disability, while trying to explain the underlying mechanisms, both from a metabolic and social angle. The literature was reviewed from inception to May 2022 using different electronic databases, not excluding the grey literature. Two independent researchers assessed the eligibility of 28 retrieved articles based on inclusion criteria; only 10 met the eligibility requirements. Different levels of coffee consumption were considered as exposure(s) and comparator(s) according to PECO concepts, while middle age was an inclusion criterion (40+ years). No limitations were set on the tool(s) assessing physical functioning, type of dietary assessment(s), study setting, general health status, country, and observational study design (cohort, cross-sectional). The cross-sectional design outnumbered the longitudinal (90%, n = 9/10). The overall quality rating was judged poor (70%) to good (30%). It was found that higher exposure to coffee drinking is strongly associated with better physical functioning outcomes, and the findings showed consistency in the direction of association across selected reports. Countering physical decline is a considerable challenge in easing the burden of population aging. For preventive models that aim to allow a better lifestyle, it has to be kept in mind that increased coffee consumption does not lead to poor physical functioning.
身体机能下降贯穿晚年生活的显著阶段，作为一个可利用的可改变因素，生活方式起着关键作用。本研究旨在进行一项系统综述，调查咖啡消费水平与衰老过程中身体机能下降状况（如肌肉减少症、衰弱、虚弱、跌倒和残疾）之间的关联，同时试图从代谢和社会角度解释其潜在机制。使用不同的电子数据库对从开始到2022年5月的文献进行了综述，不排除灰色文献。两名独立研究人员根据纳入标准评估了检索到的28篇文章的合格性；只有10篇符合合格要求。根据PECO概念，将不同水平的咖啡消费视为暴露因素和对照因素，同时将中年作为纳入标准（40岁及以上）。对评估身体机能的工具、饮食评估类型、研究环境、一般健康状况、国家以及观察性研究设计（队列研究、横断面研究）均未设限；横断面设计的数量超过纵向设计（90%，n = 9/10）。总体质量评级被判定为差（70%）到好（30%）。研究发现，较高的咖啡饮用暴露与更好的身体机能结果密切相关，并且研究结果在所选报告的关联方向上具有一致性。应对身体机能下降是减轻人口老龄化负担的一项重大挑战。对于旨在实现更好生活方式的预防模式，必须牢记增加咖啡消费不会导致身体机能变差。
