Gubatan John, Boye Theresa Louise, Temby Michelle, Sojwal Raoul S, Holman Derek R, Sinha Sidhartha R, Rogalla Stephan R, Nielsen Ole Haagen
Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Department of Gastroenterology, Medical Section, Herlev Hospital, University of Copenhagen, DK-2730 Copenhagen, Denmark.
Microorganisms. 2022 Jul 7;10(7):1371. doi: 10.3390/microorganisms10071371.
The gut microbiome has increasingly been recognized as a critical and central factor in inflammatory bowel disease (IBD). Here, we review specific microorganisms that have been suggested to play a role in the pathogenesis of IBD and the current state of fecal microbial transplants as a therapeutic strategy in IBD. We discuss specific nutritional and dietary interventions in IBD and their effects on gut microbiota composition. Finally, we examine the role and mechanisms of the gut microbiome in mediating colitis-associated colon cancer.
肠道微生物群越来越被认为是炎症性肠病（IBD）的关键核心因素。在此，我们综述了已被认为在IBD发病机制中起作用的特定微生物，以及粪便微生物移植作为IBD治疗策略的现状。我们讨论了IBD中的特定营养和饮食干预及其对肠道微生物群组成的影响。最后，我们研究了肠道微生物群在介导结肠炎相关结肠癌中的作用和机制。
