Le Bars Pierre, Kouadio Alain Ayepa, Bandiaky Octave Nadile, Le Guéhennec Laurent, de La Cochetière Marie-France
Department of Prosthetic Dentistry, Faculty of Dentistry, Nantes University, 1 Place Alexis Ricordeau, 44042 Nantes, France.
Department of Prosthetic Dentistry, Faculty of Dentistry, CHU, Abidjan P.O. Box 612, Côte d'Ivoire.
Microorganisms. 2022 Jul 16;10(7):1437. doi: 10.3390/microorganisms10071437.
Denture-related stomatitis, which has been described clinically in the literature, is either localized or generalized inflammation of the oral mucosa in connection with a removable prosthesis. During this inflammatory process, the mycobacterial biofilm and the host's immune response play an essential role. Among microorganisms of this mixed biofilm, the species proliferates easily and changes from a commensal to an opportunistic pathogen. In this situation, the relationship between the spp. and the host is influenced by the presence of the denture and conditioned both by the immune response and the oral microbiota. Specifically, this fungus is able to hijack the innate immune system of its host to cause infection. Additionally, older edentulous wearers of dentures may experience an imbalanced and decreased oral microbiome diversity. Under these conditions, the immune deficiency of these aging patients often promotes the spread of commensals and pathogens. The present narrative review aimed to analyze the innate and adaptive immune responses of patients with denture stomatitis and more particularly the involvement of sp. associated with this pathology.
义齿性口炎在文献中已有临床描述，是与可摘义齿相关的口腔黏膜局限性或全身性炎症。在这个炎症过程中，分枝杆菌生物膜和宿主的免疫反应起着至关重要的作用。在这种混合生物膜的微生物中，该菌种易于增殖，并从共生菌转变为机会致病菌。在这种情况下，该菌种与宿主之间的关系受到义齿存在的影响，并受到免疫反应和口腔微生物群的制约。具体而言，这种真菌能够劫持其宿主的先天免疫系统以引起感染。此外，佩戴义齿的老年无牙患者可能会经历口腔微生物群多样性的失衡和减少。在这些情况下，这些老年患者的免疫缺陷往往会促进共生菌和病原体的传播。本叙述性综述旨在分析义齿性口炎患者的先天和适应性免疫反应，尤其是与这种病理相关的该菌种的参与情况。
