Manikandan Saranya, Vinesh E, Selvi D Thamarai, Kannan R Kamala, Jayakumar Arun, Dinakaran J
Department of Oral Pathology, Vivekanandha Dental College for Women, Tiruchengode, Tamil Nadu, India.
Dental Wing Panimalar Medical College, Chennai, Tamil Nadu, India.
J Pharm Bioallied Sci. 2022 Jul;14(Suppl 1):S702-S705. doi: 10.4103/jpbs.jpbs_781_21. Epub 2022 Jul 13.
A denture wearer is highly prone to develop -associated denture stomatitis (CADS) due to the conversion of the normal oral commensal spp. into a pathogen under favorable conditions. Immuno-compromised status, trauma from the prosthesis, other systemic conditions, and improper maintenance of the dentures by the patient are few of the causative agents which turn the oral balance into an unhealthy and unsuitable foundation for the wearing of the prosthesis.
The objective of this study was to compare subjects wearing complete dentures and nondenture wearers regarding isolates associated with disease and colonization among the different age groups.
A cross-sectional study was conducted among 60 subjects, 30 wearing complete dentures (Group-A) and 30 nondentures wearers (Group-B), were matched for gender, race, and age. The unstimulated saliva sample was collected and cultured in CHROMagar using standard protocols.
The mean value of the candidal colony-forming units with respect to Group A is 0.36 ± 2.008, krusei 0.27 ± 1.061, value Group B: 0.73 ± 2.196, 0.36 ± 1.084. There was a significant relation between denture wearers and heavy growth of and in saliva culture with a value of P-0.054 and P-0.036, respectively.
These results indicate that denture wearers with oral had a higher prevalence of CADS. Patients with removable prostheses should be informed about the importance of proper prosthesis and personal hygiene since dentures and age-related immunosuppression are both well-known risk factors associated with candidiasis development, the presence of yeast, even in healthy denture wearers, should be considered a risk factor for denture stomatitis that increases with the duration of denture use.
由于正常口腔共生菌在有利条件下转变为病原体，假牙佩戴者极易患上与假牙相关的义齿性口炎（CADS）。免疫功能低下状态、假牙造成的创伤、其他全身性疾病以及患者对假牙维护不当等都是导致口腔平衡转变为不利于佩戴假牙的不健康和不适合状态的致病因素。
本研究的目的是比较佩戴全口假牙的受试者和未佩戴假牙者在不同年龄组中与疾病和定植相关的分离株情况。
对60名受试者进行了一项横断面研究，其中30名佩戴全口假牙（A组），30名未佩戴假牙（B组），两组在性别、种族和年龄方面进行了匹配。按照标准方案收集未刺激的唾液样本并在CHROMagar中培养。
A组念珠菌菌落形成单位的平均值为0.36±2.008，克鲁斯念珠菌为0.27±1.061；B组相应值为0.73±2.196，0.36±1.084。假牙佩戴者与唾液培养中白色念珠菌和克鲁斯念珠菌的大量生长之间存在显著关系，P值分别为0.054和0.036。
这些结果表明，患有口腔念珠菌感染的假牙佩戴者患CADS的患病率更高。应告知可摘义齿患者正确佩戴义齿和保持个人卫生的重要性，因为假牙和与年龄相关的免疫抑制都是与念珠菌病发展相关的众所周知的危险因素，即使在健康的假牙佩戴者中，酵母的存在也应被视为义齿性口炎的危险因素，且其随着假牙使用时间的延长而增加。
