Penton Kathryn E, Kinler Zachary, Davis Amber, Spiva Joshua A, Hamilton Sharon K
Department of Chemistry and Physics, Delta State University, Cleveland, MS 38733, USA.
Department of Chemistry and Physics, Ouachita Baptist University, Arkadelphia, AR 71998, USA.
Polymers (Basel). 2022 Jul 6;14(14):2773. doi: 10.3390/polym14142773.
Electrospinning natural polymers represents a developing interest in the field of biomaterials. Electrospun nanofibers have been shown to facilitate tissue regeneration and emulate body tissue, making them ideal for modern biomedical applications. These water-soluble natural polymers including alginate, have also shown promise as drug delivery vehicles. However, many biopolymers including alginate are inherently charged, making the formation of nanofibers difficult. To better understand the potential of natural polymer-based fibers in drug delivery applications, fiber formulations and drug loading concentrations of alginate-based scaffolds were investigated. It was found electrospinning poly(vinyl alcohol) with alginate facilitated fiber formation while the co-polymer agarose showed minor improvement in terms of alginate electrospinnability. Once uniform fibers were formed, the antibiotic ciprofloxacin was added into the polymer electrospinning solution to yield drug-loaded nanofibers. These optimized parameters coupled with small molecule release rate data from the drug-loaded, alginate-based fibers have been used to establish a catalog of small molecule release profiles. In the future, this catalog will be further expanded to include drug release rate data from other innately charged natural polymer-based fibers such as chitosan. It is anticipated that the cataloged profiles can be applied in the further development of biomaterials used in drug delivery.
静电纺丝天然聚合物在生物材料领域正引发越来越多的关注。静电纺纳米纤维已被证明有助于组织再生并模拟人体组织，使其成为现代生物医学应用的理想选择。这些水溶性天然聚合物，包括藻酸盐，也已显示出作为药物递送载体的潜力。然而，许多生物聚合物，包括藻酸盐，本质上都带有电荷，这使得纳米纤维的形成变得困难。为了更好地理解基于天然聚合物的纤维在药物递送应用中的潜力，研究了藻酸盐基支架的纤维配方和药物负载浓度。研究发现，将聚乙烯醇与藻酸盐一起进行静电纺丝有助于纤维形成，而共聚物琼脂糖在藻酸盐的可静电纺丝性方面显示出轻微改善。一旦形成均匀的纤维，就将抗生素环丙沙星添加到聚合物静电纺丝溶液中，以制备载药纳米纤维。这些优化参数以及来自载药藻酸盐基纤维的小分子释放速率数据已被用于建立小分子释放曲线目录。未来，该目录将进一步扩展，以纳入来自其他固有带电的基于天然聚合物的纤维（如壳聚糖）的药物释放速率数据。预计编目的曲线可应用于药物递送中生物材料的进一步开发。
