National Veterinary Institute, Technical University of Denmark, Lindholm, DK-4771 Kalvehave, Denmark.
Statens Serum Institute, Artillerivej 5, DK-2300 Copenhagen S, Denmark.
Viruses. 2022 Jun 25;14(7):1387. doi: 10.3390/v14071387.
African swine fever is an important viral disease of wild and domestic pigs. To gain further knowledge of the properties of the currently circulating African swine fever virus (ASFV), experimental infections of young pigs (approximately 8 weeks of age) and pregnant sows (infected at about 100 days of gestation) with the genotype II ASFV Georgia/2007 were performed. The inoculated young pigs developed typical clinical signs of the disease and the infection was transmitted (usually within 3-4 days) to all of the "in contact" animals that shared the same pen. Furthermore, typical pathogical lesions for ASFV infection were found at necropsy. Inoculation of pregnant sows with the same virus also produced rapid onset of disease from post-infection day three; two of the three sows died suddenly on post-infection day five, while the third was euthanized on the same day for animal welfare reasons. Following necropsy, the presence of ASFV DNA was detected in tonsils, spleen and lymph nodes of some of the fetuses, but the levels of viral DNA were much lower than in these tissues from the sows. Thus, only limited transplacental transmission occurred during the course of this experiment. These studies contribute towards further understanding about the spread of this important viral disease in domestic pigs.
非洲猪瘟是一种重要的野生和家养猪病毒性疾病。为了进一步了解目前流行的非洲猪瘟病毒（ASFV）的特性，我们用基因型 II 的格鲁吉亚/2007 型 ASFV 对小猪（约 8 周龄）和妊娠母猪（在妊娠约 100 天时感染）进行了实验感染。接种的小猪出现了典型的疾病临床症状，感染在 3-4 天内传播给了共享同一个猪圈的所有“接触”动物。此外，在剖检时发现了典型的 ASFV 感染病理病变。用相同的病毒接种妊娠母猪也会导致疾病在感染后第三天迅速发病；其中 3 头母猪中的 2 头在感染后第 5 天突然死亡，而第 3 头由于动物福利原因在同一天被安乐死。剖检后，在一些胎儿的扁桃体、脾脏和淋巴结中检测到了 ASFV DNA，但病毒 DNA 的水平比来自母猪的这些组织中的低得多。因此，在这个实验过程中仅发生了有限的胎盘传播。这些研究有助于进一步了解这种重要的猪病毒性疾病在家猪中的传播。
