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2018 年至 2021 年中国中南部猪肠道病毒的流行和进化特征。

Epidemic and Evolutionary Characteristics of Swine Enteric Viruses in South-Central China from 2018 to 2021.

机构信息

Key Laboratory of Prevention and Control Agents for Animal Bacteriosis (Ministry of Agriculture and Rural Affairs), Institute of Animal Husbandry and Veterinary, Hubei Academy of Agricultural Sciences, Wuhan 430064, China.

Hubei Provincial Key Laboratory of Animal Pathogenic Microbiology, Wuhan 430064, China.

出版信息

Viruses. 2022 Jun 28;14(7):1420. doi: 10.3390/v14071420.

DOI:10.3390/v14071420
PMID:35891398
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9323342/
Abstract

Swine enteric viruses are a major cause of piglet diarrhea, causing a devastating impact on the pork industry. To further understand the molecular epidemiology and evolutionary diversity of swine enteric viruses, we carried out a molecular epidemiological investigation of swine enteric viruses (PEDV, PDCoV, PoRVA, and TGEV) on 7107 samples collected from pig farms in south-central China. The results demonstrated that PEDV is the predominant pathogen causing piglet diarrhea, and its infection occurs mainly in relatively cold winter and spring in Hunan and Hubei provinces. The positive rate of PEDV showed an abnormal increase from 2020 to 2021, and that of PoRVA and PDCoV exhibited gradual increases from 2018 to 2021. PEDV-PoRVA and PEDV-PDCoV were the dominant co-infection modes. A genetic evolution analysis based on the PEDV S1 gene and ORF3 gene revealed that the PEDV GII-a is currently epidemic genotype, and the ORF3 gene of DY2020 belongs to a different clade relative to other GII-a strains isolated in this study. Overall, our results indicated that the variant PEDV GII-a is the main pathogen of piglet diarrhea with a trend of outbreak. G9 is the dominant PoRVA genotype and has the possibility of outbreak as well. It is therefore critical to strengthen the surveillance of PEDV and PoRVA, and to provide technical reserves for the prevention and control of piglet diarrhea.

摘要

猪肠道病毒是仔猪腹泻的主要原因，对养猪业造成了毁灭性的影响。为了进一步了解猪肠道病毒（PEDV、PDCoV、PoRVA 和 TGEV）的分子流行病学和进化多样性，我们对来自中国中南部农场的 7107 个样本进行了猪肠道病毒的分子流行病学调查。结果表明，PEDV 是引起仔猪腹泻的主要病原体，其感染主要发生在湖南和湖北相对寒冷的冬春季节。PEDV 的阳性率从 2020 年到 2021 年呈异常增加，PoRVA 和 PDCoV 的阳性率从 2018 年到 2021 年逐渐增加。PEDV-PoRVA 和 PEDV-PDCoV 是主要的共同感染模式。基于 PEDV S1 基因和 ORF3 基因的遗传进化分析表明，PEDV GII-a 是目前流行的基因型，而 DY2020 的 ORF3 基因与本研究中分离的其他 GII-a 株属于不同的分支。总的来说，我们的结果表明，变异的 PEDV GII-a 是仔猪腹泻的主要病原体，且有爆发的趋势。G9 是主要的 PoRVA 基因型，也有爆发的可能性。因此，加强对 PEDV 和 PoRVA 的监测，并为仔猪腹泻的防控提供技术储备至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dff2/9323342/eb430338b2b6/viruses-14-01420-g007.jpg
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