Labkovskiĭ B M, Danova L A, Gershanovich M L, Kondrat'ev V B
Antibiotiki. 1978 Sep;23(9):851-4.
Carminomycin chemotherapy of the patients with malignant tumors is often complicated with cardiopathy which is sometimes assymptomic and registered only electrocardiographycally. Chemotherapy on the background of reparative regeneration stimulators from the series of synthetic pyrrimidine derivatives, such as methyluracyl for oral use and a soluble salt of methyluracyl for parenteral administration significantly decreased the rate of the cardiotoxic complications and promoted a decrease in their level. The use of methyluracyl and its soluble salt did not decrease the therapeutic effect of carminomycin. Methyluracyl and its soluble salt may be recommended for prophylaxis of cardiotoxic complications in chemotherapy of malignant tumors with carminomycin.
恶性肿瘤患者进行柔红霉素化疗时常常并发心脏病，有时并无症状，仅通过心电图检查才能发现。在使用一系列合成嘧啶衍生物（如口服的甲基尿嘧啶和用于肠胃外给药的甲基尿嘧啶可溶性盐）作为修复再生刺激剂的背景下进行化疗，可显著降低心脏毒性并发症的发生率，并促使其程度减轻。使用甲基尿嘧啶及其可溶性盐并不会降低柔红霉素的治疗效果。甲基尿嘧啶及其可溶性盐可推荐用于预防柔红霉素治疗恶性肿瘤时的心脏毒性并发症。
