Bath Harjot, Jawandha Khushmanjit, Elhassan Mohammed G
Internal Medicine, Saint Agnes Medical Center, Fresno, USA.
Internal Medicine, California Health Sciences University, Fresno, USA.
Cureus. 2022 Jun 20;14(6):e26132. doi: 10.7759/cureus.26132. eCollection 2022 Jun.
Drug-induced pancreatitis (DIP), while not a major cause of acute pancreatitis, remains a debilitating diagnosis resulting in significant patient morbidity and mortality. The diagnosis includes first diagnosing acute pancreatitis, second ruling out more common etiologies (alcohol abuse, gallstones, etc.), and third documenting a thorough history (in particular medications). Essentially, it is a diagnosis of exclusion. Any drugs with the potential to result in acute pancreatitis should be discontinued, and those without future recurrence of pancreatitis are deemed to have had a drug-induced case. Although the exact pathophysiology of the initial development of DIP is unknown, we hypothesize it is different for various drug classes. It is known that once pancreatic enzymes are activated after insult, they activate an inflammatory response resulting in auto-digestion of the pancreas. Our report discusses a previously not documented case of DIP in a patient on hydroxyurea monotherapy for the treatment of Janus kinase 2 (JAK2) essential thrombocytosis.
药物性胰腺炎（DIP）虽不是急性胰腺炎的主要病因，但仍是一种使人虚弱的诊断，会导致患者出现显著的发病率和死亡率。该诊断包括：首先诊断出急性胰腺炎，其次排除更常见的病因（酗酒、胆结石等），第三记录详尽的病史（特别是用药情况）。本质上，这是一种排除性诊断。任何有可能导致急性胰腺炎的药物都应停用，那些停用后胰腺炎未再次发作的患者则被视为药物性胰腺炎病例。尽管DIP初始发病的确切病理生理学尚不清楚，但我们推测不同药物类别引发的机制不同。已知胰腺在受到损伤后一旦胰酶被激活，就会引发炎症反应，导致胰腺自身消化。我们的报告讨论了一例此前未记录的DIP病例，该患者正在接受羟基脲单药治疗，以治疗JAK2基因相关的原发性血小板增多症。
