Qu Shuai-Ling, Li Su-Su, Li Dong, Zhao Pei-Ji
State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, School of Life Sciences, Yunnan University, Kunming 650091, China.
Microorganisms. 2022 Jul 24;10(8):1489. doi: 10.3390/microorganisms10081489.
The genus is a group of ascomycete parasitic fungi, and all known species of this genus are endoparasites; they mainly feed on insects or arthropods and a few feed on other fungi. Fungi of this genus have evolved highly specific and complex mechanisms to escape their host's immune system and coordinate their life cycle coefficients with those of their hosts for survival and reproduction; this mechanism has led to the production of distinctive metabolites in response to the host's defenses. Herein, we review approximately 131 metabolites discovered in the genus (including mycelium, fruiting bodies and fungal complexes) in the past 15 years, which can be used as an important source for new drug research and development. We summarize chemical structures, bioactivity and the potential application of these natural metabolites. We have excluded some reports that originally belonged to , but whose taxonomic attribution is no longer the genus. This can and will serve as a resource for drug discovery.
该属是一群子囊菌寄生真菌，该属所有已知物种均为内寄生菌；它们主要以昆虫或节肢动物为食，少数以其他真菌为食。该属真菌已经进化出高度特异性和复杂的机制来逃避宿主的免疫系统，并使其生命周期系数与宿主的系数相协调以实现生存和繁殖；这种机制导致了响应宿主防御而产生独特的代谢产物。在此，我们综述了过去15年在该属（包括菌丝体、子实体和真菌复合体）中发现的约131种代谢产物，它们可作为新药研发的重要来源。我们总结了这些天然代谢产物的化学结构、生物活性和潜在应用。我们排除了一些最初属于该属但分类归属已不再是该属的报告。这可以而且将作为药物发现的资源。
