Department of Food Science and Technology, Institute of Food Safety and Nutrition, College of Science & Engineering, College of Life Science and Technology, Jinan University, Guangzhou 510632, P.R. China.
Institute of Microbiology, Guangdong Academy of Sciences, State Key Laboratory of Applied Microbiology Southern China, Guangdong, Guangdong Provincial Key Laboratory of Microbial Safety and Health, Key Laboratory of Agricultural Microbiomics and Precision Application, Ministry of Agriculture and Rural Affairs, Guangzhou 510070, P.R. China.
J Agric Food Chem. 2022 Mar 16;70(10):3194-3206. doi: 10.1021/acs.jafc.1c08393. Epub 2022 Mar 3.
Increasing attention focuses on the relationship between neuroinflammation and Alzheimer's disease (AD). The reports on the microbiota-gut-brain axis reveal that the regulation by gut microbiota is an effective way to intervene in neuroinflammation-related AD. In this study, two novel selenium peptides (Se-Ps), VPRKL()M (Se-P1) and RYNA()MNDYT (Se-P2), with neuroprotection effects were obtained from Se-enriched . Se-P1 and Se-P2 pre-protection led to a 30 and 33% increase in the PC-12 cell viability compared to the damage group, respectively. Moreover, Se-Ps exhibited a significant pre-protection against LPS-induced inflammatory and oxidative stress in the colon and brain by inhibiting the production of pro-inflammatory mediators ( < 0.05) and malondialdehyde, as well as promoting anti-inflammatory cytokine level and antioxidant enzyme activity ( < 0.05), which may alleviate the cognitive impairment in LPS-injured mice ( < 0.05). Se-Ps not only repaired the intestinal mucosa damage of LPS-injured mice but also had a positive effect on gut microbiota dysbacteriosis by increasing the abundance of and and decreasing the abundance of and . Collectively, the antioxidant, anti-inflammatory, and regulating properties on gut microflora of Se-Ps contribute to their neuroprotection, supporting that Se-Ps could be a promising dietary supplement in the prevention and/or treatment of AD.
越来越多的注意力集中在神经炎症与阿尔茨海默病（AD）之间的关系上。有关微生物群-肠-脑轴的报告表明，肠道微生物群的调节是干预与神经炎症相关的 AD 的有效方法。在这项研究中，从富硒 中获得了两种具有神经保护作用的新型硒肽（Se-Ps），VPRKL()M（Se-P1）和 RYNA()MNDYT（Se-P2）。与损伤组相比，Se-P1 和 Se-P2 的预保护分别使 PC-12 细胞活力增加了 30%和 33%。此外，Se-Ps 通过抑制促炎介质的产生（<0.05）和丙二醛，以及促进抗炎细胞因子水平和抗氧化酶活性（<0.05），对 LPS 诱导的结肠和大脑炎症和氧化应激表现出显著的预保护作用，这可能减轻 LPS 损伤小鼠的认知障碍（<0.05）。Se-Ps 不仅修复了 LPS 损伤小鼠的肠黏膜损伤，而且通过增加 和 的丰度，降低 和 的丰度，对肠道微生物群失调也有积极影响。总之，Se-Ps 的抗氧化、抗炎和调节肠道微生物群特性有助于其神经保护作用，这表明 Se-Ps 可能是预防和/或治疗 AD 的有前途的膳食补充剂。
