Le Trung Hieu, Thi Tran Thi Van, Tran Van Khoa, Vu Ho Xuan Anh, Tran Thanh Minh, Chau Nguyen Dang Giang, Chuong Nguyen Thi Hong, Varma Rajender S, Trinh Tam Kiet, Ho Thanh-Tam, Hac Nguyen Thi Bach, Ahamad Tansir, Nguyen Chinh Chien, Le Quyet Van
Faculty of Chemistry, Hue University of Sciences, Hue University, Thua Thien Hue 530000, Vietnam.
Institute of Research and Development, Duy Tan University, Da Nang 550000, Vietnam.
ACS Omega. 2022 Mar 11;7(11):9397-9405. doi: 10.1021/acsomega.1c06651. eCollection 2022 Mar 22.
A novel polysaccharide structure (PS-T80) was collected from biomass and characterized via a combination of chemical and spectral analyses. Employing high-performance gel permeation chromatography (HPGPC), the average molecular weight is proven to be 7.4 × 10 Da. Furthermore, a sugar composition analysis of the obtained polysaccharide suggests two main sugars, β-d-glucose and α-d-mannose, at a molar ratio of 2:1, respectively, in the backbone. The structure analysis unveils that PS-T80 is a mannoglucan, possessing the repeating unit of [→3)-β-d-Glcp-(1 → 3)-α-d-Manp-(1 → 3)-β-d-Glcp-(1→] . Such a configuration could be considered a novel polysaccharide. Impressively, antioxidant tests revealed that PS-T80 has a promising antioxidant activity. These results demonstrate that the obtained PS is a potential bioactive material for biomedical applications.
从生物质中提取了一种新型多糖结构(PS-T80),并通过化学和光谱分析相结合的方法对其进行了表征。采用高效凝胶渗透色谱法(HPGPC),证明其平均分子量为7.4×10 Da。此外,对所得多糖的糖组成分析表明,主链中有两种主要糖类,即β-d-葡萄糖和α-d-甘露糖,摩尔比分别为2:1。结构分析表明,PS-T80是一种甘露葡聚糖,具有[→3)-β-d-葡萄糖-(1→3)-α-d-甘露糖-(1→3)-β-d-葡萄糖-(1→]的重复单元。这种结构可被视为一种新型多糖。令人印象深刻的是,抗氧化测试表明PS-T80具有良好的抗氧化活性。这些结果表明,所获得的PS是一种潜在的生物医学应用生物活性材料。