Morimoto Misako, Kato Atsushi, Nogami Kotoe, Akaike Yuta, Furusawa Takaaki, Kojima Hiroe, Sasakawa Chihiro
Nippon Institute for Biological Science, 9-2221-1 Shin-machi, Ome 198-0024, Tokyo, Japan.
Biomedical Science Association, 2-20-8-3F Kamiosaki, Shinagawa-ku 141-0021, Tokyo, Japan.
Vet Sci. 2022 Jul 26;9(8):382. doi: 10.3390/vetsci9080382.
causes swine erysipelas (SE). Sporadic SE outbreaks in Japan are mostly caused by the serovar 1a variant featured by methionine (M) and isoleucine (I) at amino acid positions 203 and 257 of the surface protective antigen (Spa) A protein (M203/I257 SpaA-type). To determine if current vaccines are effective against infection with this variant in pigs, one representative inactivated vaccine, SER-ME (containing serovar 2a), was evaluated. All vaccinated pigs survived without any apparent clinical signs after lethal challenge with the Fujisawa reference strain or the variant. This indicates that the SER-ME vaccine effectively protects pigs against the infection of M203/I257 SpaA-type variant. Current vaccines in Japan, including SER-ME, suggest that outbreaks in Japan are unlikely caused by vaccine failure.
引起猪丹毒（SE）。日本散发性SE疫情大多由表面保护性抗原（Spa）A蛋白第203和257位氨基酸处为甲硫氨酸（M）和异亮氨酸（I）的血清型1a变体所致（M203/I257 SpaA型）。为确定当前疫苗对猪感染该变体是否有效，评估了一种代表性灭活疫苗SER-ME（含血清型2a）。用藤泽参考菌株或该变体进行致死性攻毒后，所有接种疫苗的猪均存活且无明显临床症状。这表明SER-ME疫苗能有效保护猪免受M203/I257 SpaA型变体的感染。日本目前的疫苗，包括SER-ME，表明日本的疫情不太可能是由疫苗失效引起的。
