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绘制肢端黑色素瘤的单细胞图谱，并分析肿瘤微环境的分子调控网络。

Mapping the single-cell landscape of acral melanoma and analysis of the molecular regulatory network of the tumor microenvironments.

机构信息

Department of Dermatology, The First Medical General Hospital of People's Liberation Army, Beijing, China.

Beijing Institute of Genomics & China National Center for Bioinformation, Chinese Academy of Sciences, Beijing, China.

出版信息

Elife. 2022 Jul 27;11:e78616. doi: 10.7554/eLife.78616.

DOI:10.7554/eLife.78616
PMID:35894206
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9398445/
Abstract

Acral melanoma (AM) exhibits a high incidence in Asian patients with melanoma, and it is not well treated with immunotherapy. However, little attention has been paid to the characteristics of the immune microenvironment in AM. Therefore, in this study, we collected clinical samples from Chinese patients with AM and conducted single-cell RNA sequencing to analyze the heterogeneity of its tumor microenvironments (TMEs) and the molecular regulatory network. Our analysis revealed that genes, such as , , , and could drive the deregulation of various TME components. The molecular interaction relationships between TME cells, such as MIF-CD44 and TNFSF9-TNFRSF9, might be an attractive target for developing novel immunotherapeutic agents.

摘要

肢端黑色素瘤（AM）在亚洲黑色素瘤患者中发病率较高，且免疫疗法对此疗效不佳。然而，人们对 AM 肿瘤微环境（TME）的免疫特征关注较少。因此，在本研究中，我们收集了中国 AM 患者的临床样本，并进行了单细胞 RNA 测序，以分析其 TME 的异质性和分子调控网络。我们的分析表明，基因如 、 、 、 等可能驱动各种 TME 成分的失调。MIF-CD44 和 TNFSF9-TNFRSF9 等 TME 细胞的分子相互作用关系可能是开发新型免疫治疗药物的有吸引力的靶点。

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