Divisão de Medicina Veterinária, Guarda Nacional Republicana (GNR), Lisbon, Portugal.
Mediterranean Institute for Agriculture, Environment and Development (MED), Instituto de Investigação e Formação Avançada, Universidade de Évora, Évora, Portugal.
Am J Vet Res. 2022 Jun 28;83(8):ajvr.22.03.0036. doi: 10.2460/ajvr.22.03.0036.
To evaluate photobiomodulation therapy in dogs with bilateral hip osteoarthritis.
20 dogs.
Forty joints were assigned to a control group (CG; n = 20) or treatment group (photobiomodulation therapy [PBMT]; 20). CG received a 21-day course of meloxicam, and PBMT received treatment with a Class IV therapeutic laser over 3 weeks. Joint range of motion, thigh girth, the Canine Brief Pain Inventory (divided into pain interference score [PIS] and pain severity score [PSS]), Hudson Visual Analogue Scale, Liverpool Osteoarthritis in Dogs, and Canine Orthopedic Index (COI; divided into function, gait, stiffness, and quality of life) were evaluated before treatment, +8, +15, +30, +60, and +90 days after initial treatment. Results were analyzed with repeated measures ANOVA or Wilcoxon signed ranks test, P < 0.05. Kaplan-Meier estimators were compared with the Breslow test.
Patients had a mean age of 8.3 ± 1.9 years and body weight of 65.7 ± 12.1lb. Osteoarthritis was classified as moderate (n = 26) and severe (14). No differences were found at time 0. Better results were observed in PBMT at +8 days (P = 0.01 for PSS, P = 0.04 for function and COI), +15 days (P = 0.01 for PSS and function, P = 0.02 for PIS and function, P = 0.03 for COI and P = 0.04 for Liverpool Osteoarthritis in Dogs [LOAD]) and +30 days (P = 0.01 for function and gait, P = 0.02 for COI, and P = 0.04 for PIS, PSS, and LOAD). Joint range of motion improved in PBMT from +15 to 90 days. Kaplan-Meier estimators showed that PBMT produced longer periods with better results.
PBMT reduced pain levels and improved clinical findings in dogs with hip osteoarthritis.
评估光生物调节疗法在双侧髋关节骨关节炎犬中的应用效果。
20 只狗。
将 40 个关节分配到对照组（CG；n=20）或治疗组（光生物调节疗法[PBMT]；20）。CG 接受 21 天美洛昔康治疗，PBMT 在 3 周内接受 IV 级治疗激光治疗。在治疗前、治疗后+8、+15、+30、+60 和+90 天评估关节活动度、大腿围、犬简短疼痛量表（分为疼痛干扰评分[PIS]和疼痛严重程度评分[PSS]）、Hudson 视觉模拟量表、利物浦犬骨关节炎和犬骨科指数（COI；分为功能、步态、僵硬和生活质量）。结果采用重复测量方差分析或 Wilcoxon 符号秩检验进行分析，P<0.05。Kaplan-Meier 估计值与 Breslow 检验进行比较。
患者平均年龄为 8.3±1.9 岁，体重为 65.7±12.1 磅。骨关节炎分类为中度（n=26）和重度（n=14）。在时间 0 时未发现差异。在 PBMT 中，在+8 天（P=0.01 用于 PSS，P=0.04 用于功能和 COI）、+15 天（P=0.01 用于 PSS 和功能，P=0.02 用于 PIS 和功能，P=0.03 用于 COI 和 P=0.04 用于利物浦犬骨关节炎[LOAD]）和+30 天（P=0.01 用于功能和步态，P=0.02 用于 COI，P=0.04 用于 PIS、PSS 和 LOAD）时观察到更好的结果。从+15 天到 90 天，PBMT 增加了关节活动度。Kaplan-Meier 估计值表明 PBMT 产生了更长的更好结果期。
PBMT 降低了髋关节骨关节炎犬的疼痛水平并改善了临床发现。
