Alves J C, Santos Ana, Lavrador Catarina, Carreira L Miguel
Divisão de Medicina Veterinária, Guarda Nacional Republicana (GNR), Rua Presidente Arriaga, 9, 1200-771 Lisbon, Portugal.
Faculty of Veterinary Medicine, Lusófona University, 1749-024 Lisbon, Portugal.
Animals (Basel). 2023 Dec 29;14(1):128. doi: 10.3390/ani14010128.
In this retrospective study to determine the optimal method of evaluating static weight-bearing distribution to assess response to treatment in dogs with osteoarthritis using a weight distribution platform, data from the Clinica Veterinária de Cães (Portuguese Republican National Guard) clinical records were extracted. At baseline and at 15 days post-treatment, follow-up data from 80 dogs treated for bilateral hip osteoarthritis were categorized based on an anchor question. Estimates of minimal clinically important differences were calculated with distribution-based and anchor-based methods for deviation from normal weight-bearing and a symmetry index (SI). For deviation, the anchor-based methods provided a range from -0.3 to -3.1, and the distribution-based methods from 0.16 to 0.29. For SI, the anchor-based methods provided a range from -10.0 to -23.9, and the distribution-based methods from 1.31 to 2.88. Receiver operator characteristic curves provided areas under the curve >0.7, indicating an acceptable cut-off point. We presented estimates of -1 for deviation and -10 for SI in dogs with OA. These estimates can be used for research and patient monitoring. Future studies should include OA from other joints and animals from a broader clinical context.
在这项回顾性研究中，为了确定使用体重分布平台评估静态负重分布以评估骨关节炎犬治疗反应的最佳方法，我们提取了来自Clinica Veterinária de Cães（葡萄牙共和国国民警卫队）临床记录的数据。在基线和治疗后15天，对80只接受双侧髋关节骨关节炎治疗的犬的随访数据根据一个关键问题进行分类。采用基于分布和基于关键指标的方法计算了与正常负重偏差和对称指数（SI）的最小临床重要差异估计值。对于偏差，基于关键指标的方法得出的范围为-0.3至-3.1，基于分布的方法为0.16至0.29。对于SI，基于关键指标的方法得出的范围为-10.0至-23.9，基于分布的方法为1.31至2.88。受试者工作特征曲线下面积>0.7，表明有可接受的截断点。我们给出了骨关节炎犬偏差估计值为-1和SI估计值为-10的结果。这些估计值可用于研究和患者监测。未来的研究应纳入来自其他关节的骨关节炎以及更广泛临床背景下的动物。
