Department of Nursing, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China.
Graduate School of Medicine, University of Tennessee Medical Center, Knoxville, Tennessee, USA.
BMJ Open. 2022 Jul 27;12(7):e061261. doi: 10.1136/bmjopen-2022-061261.
To explore the interaction effect between overweight/obesity and alcohol consumption on hypertension risk.
A longitudinal study of the independent and combined effects of hypertension risk factors.
Twelve provinces in China, including Beijing Liaoning, Heilongjiang, Shanghai, Jiangsu, Shandong, Henan, Hubei, Hunan, Guangxi, Guizhou and Chongqing.
Longitudinal data of China Health and Nutrition Survey, collected between 2011 and 2015, were used in this study. A total of 13 121 residents from 12 provinces were included and completed physical examinations and questionnaires at baseline.
First incidence of hypertension.
Over a mean follow-up of 4 years, 690 incident hypertension cases were reported. After adjusting for age, gender, education level, marital status, physical activity, diabetes and smoking, high body mass index (BMI) and light drinking (OR=5.07, 95% CI 3.06 to 8.41), high waist circumference (WC) and light drinking (OR=4.81, 95% CI 2.92 to 7.91), high waist hip ratio and light drinking (OR=2.85, 95% CI 1.84 to 4.42) were the highest risk of all participants in the three combinations. Multiplicative interaction measures were statistically significant in overweight/obesity and drinking/light drinking/heavy drinking categories in men (p<0.05). Additive interactions were observed between high BMI and drinking in men (relative excess risk due to interaction=1.75, 95% CI 0.85 to 2.65, attributable proportion due to interaction=0.56, 95% CI 0.36 to 0.76, synergy index=6.43, 95% CI 1.02 to 28.84).
Measures of body weight and size, particularly BMI and WC, appear to interact synergistically with alcohol consumption to increase the risk of hypertension in the Chinese population. Given that approximately 245 million people in China have hypertension, and that hypertension is a major cause of cardiovascular disease worldwide, our results may have implications for chronic disease prevention.
探讨超重/肥胖与饮酒对高血压风险的交互作用。
一项关于高血压危险因素独立和联合作用的纵向研究。
中国 12 个省份，包括北京、辽宁、黑龙江、上海、江苏、山东、河南、湖北、湖南、广西、贵州和重庆。
本研究使用了中国健康与营养调查 2011 年至 2015 年期间收集的纵向数据。共纳入 12 个省份的 13121 名居民，他们在基线时完成了体检和问卷调查。
首次发生高血压。
在平均 4 年的随访中，报告了 690 例高血压新发病例。在调整了年龄、性别、教育程度、婚姻状况、体力活动、糖尿病和吸烟状况后，高体质指数（BMI）和轻度饮酒（OR=5.07，95%CI 3.06 至 8.41）、高腰围（WC）和轻度饮酒（OR=4.81，95%CI 2.92 至 7.91）、高腰臀比和轻度饮酒（OR=2.85，95%CI 1.84 至 4.42）是所有参与者中风险最高的三种组合。在男性中，超重/肥胖和饮酒/轻饮/重饮类别中的乘法交互作用测量值具有统计学意义（p<0.05）。在男性中，高 BMI 与饮酒之间存在相加交互作用（交互归因风险增加=1.75，95%CI 0.85 至 2.65，交互归因比例=0.56，95%CI 0.36 至 0.76，协同指数=6.43，95%CI 1.02 至 28.84）。
体重和体型指标，特别是 BMI 和 WC，似乎与饮酒协同作用，增加了中国人群患高血压的风险。鉴于中国约有 2.45 亿人患有高血压，而高血压是全球心血管疾病的主要原因，我们的研究结果可能对慢性病预防具有重要意义。
