ToxSTAR: drug-induced liver injury prediction tool for the web environment.

SUMMARY

Drug-induced liver injury (DILI) is a challenging endpoint in predictive toxicology because of the complex reactive metabolites that cause liver damage and the wide range of mechanisms involved in the development of the disease. ToxSTAR provides structural similarity-based DILI analysis and in-house DILI prediction models that predict four DILI subtypes (cholestasis, cirrhosis, hepatitis and steatosis) based on drug and drug metabolite molecules.

AVAILABILITY AND IMPLEMENTATION

ToxSTAR is freely available at https://toxstar.kitox.re.kr/.

SUPPLEMENTARY INFORMATION

Supplementary data are available at Bioinformatics online.