Instrumental Analysis Center, Dalian Polytechnic University, Dalian 116034, China; School of Light Industry and Chemical Engineering, Dalian Polytechnic University, Dalian 116034, China.
Instrumental Analysis Center, Dalian Polytechnic University, Dalian 116034, China.
J Colloid Interface Sci. 2022 Dec;627:942-955. doi: 10.1016/j.jcis.2022.07.030. Epub 2022 Jul 8.
Pressure ulcer is a common chronic injury in the bedridden population. The wound is easily subjected to secondary pressure injury due to the inconvenient mobility of patients, which greatly prolongs the hospital stay of patients and is highly prone to wound infection or other complications. It is urgent to develop a multifunctional wound dressing with pressure sensing, real-time monitoring, and wound therapy to overcome the secondary pressure injury during treatment. Here, a polyvinyl alcohol/acrylamide-ionic liquid hydrogel dressing is designed based on the antibacterial property and electrical conductivity of imidazolidine ionic liquids. Compared with existing pressure-sensing hydrogels, the hydrogel exhibits extremely high pressure sensitivity (9.19 kPa). Meanwhile, the good real-time responsiveness, stable signal output as well as excellent mechanical properties enable the hydrogel to monitor human movement on a large scale, and transmit the pressure status of patient wounds to nursing staff in a timely manner to avoid secondary pressure injuries. In addition, this hydrogel dressing exhibits a wide range of antibacterial activities against Gram-negative and Gram-positive bacteria as well as fungi, and has a significant therapeutic effect on full-thickness skin wounds by inhibiting wound infection, rapidly eradicating inflammation, promoting proliferation and tissue remodeling. This multifunctional hydrogel dressing opens a therapeutic and regulatory two-pronged strategy avenue through chronic wound management and pressure sensing monitoring.
压疮是卧床人群中常见的慢性损伤。由于患者行动不便，伤口容易受到二次压力损伤，这大大延长了患者的住院时间，且极易发生伤口感染或其他并发症。因此，迫切需要开发一种具有压力感应、实时监测和伤口治疗功能的多功能伤口敷料，以克服治疗过程中的二次压力损伤。在这里，基于咪唑啉离子液体的抗菌性和导电性，设计了一种聚乙烯醇/丙烯酰胺-离子液体水凝胶敷料。与现有的压力感应水凝胶相比，该水凝胶表现出极高的压力敏感性（9.19kPa）。同时，良好的实时响应性、稳定的信号输出以及出色的机械性能使水凝胶能够大规模监测人体运动，并将患者伤口的压力状态及时传递给护理人员，以避免二次压力损伤。此外，这种水凝胶敷料对革兰氏阴性和革兰氏阳性菌以及真菌具有广泛的抗菌活性，并通过抑制伤口感染、迅速消除炎症、促进增殖和组织重塑，对全层皮肤伤口具有显著的治疗效果。这种多功能水凝胶敷料通过慢性伤口管理和压力感应监测，为治疗和调控开辟了一条双管齐下的策略途径。
