Barański B, Sitarek K
Toxicol Lett. 1987 May;36(3):267-73. doi: 10.1016/0378-4274(87)90195-0.
Female rats were administered by gavage an aqueous solution of CdCl2 for 14 weeks, 5 days per week, at doses of 0.04, 0.4, 4 and 40 mg Cd/kg/day or exposed by inhalation to CdO for 20 weeks (5 h per days, 5 days per week) at concentrations of 0.02, 0.16 and 1 mg Cd/m3. A pronounced increase in the mean duration of the oestrous cycle mainly due to lengthening of dioestrus was noted already 6 weeks after treatment of females given per os 40 mg Cd/kg or exposed to a concentration of 1 mg Cd/m3. No changes in the mean duration of the oestrous cycle were found in other experimental groups, although in the 0.16 mg Cd/m3 group an increased percentage of females with oestrous cycles lasting over 6 days was shown 18 weeks after exposure. Since Cd-induced lethality and decrease in body weight gain were observed in females given by gavage 40 mg Cd/kg or exposed by inhalation to a concentration of 1 mg Cd/m3, it is concluded that exposure to cadmium does not affect the sexual cycle unless other overt signs of Cd-toxicity are induced.
雌性大鼠每周5天，连续14周经口灌胃给予氯化镉水溶液，剂量分别为0.04、0.4、4和40毫克镉/千克/天，或者每周5天，每天5小时，连续20周吸入氧化镉，浓度分别为0.02、0.16和1毫克镉/立方米。在经口给予40毫克镉/千克的雌性大鼠或暴露于1毫克镉/立方米浓度环境中的雌性大鼠接受处理6周后，就已观察到发情周期的平均持续时间显著增加，这主要是由于间情期延长所致。在其他实验组中未发现发情周期平均持续时间有变化，不过在暴露18周后的0.16毫克镉/立方米组中，发情周期持续超过6天的雌性大鼠百分比有所增加。由于在经口给予40毫克镉/千克的雌性大鼠或吸入1毫克镉/立方米浓度环境中的雌性大鼠中观察到镉诱导的致死率和体重增加减少，因此得出结论，除非诱导出镉毒性的其他明显迹象，否则镉暴露不会影响性周期。
