Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, San Francisco, CA, United States.
Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, United States.
Front Immunol. 2022 Jul 12;13:910383. doi: 10.3389/fimmu.2022.910383. eCollection 2022.
Human milk contains three antibody classes that confer mucosal immunity to the breastfed infant: secretory IgA (SIgA), secretory IgM (SIgM), and IgG. Influenza and pertussis vaccines administered during pregnancy induce pathogen specific SIgA and IgG responses in human milk that have been shown to protect the breastfed infant from these respiratory illnesses. In addition, mRNA vaccines against the SARS-CoV-2 virus administered during pregnancy and lactation induce anti-SARS-CoV-2 IgG and IgA responses in human milk. This review summarizes the immunologic benefits of influenza, pertussis, and COVID-19 vaccines conferred by human milk. Additionally, future research direction in human milk immunity and public health needs to improve lactational support are discussed.
人乳含有三种抗体类别，可赋予母乳喂养婴儿黏膜免疫：分泌型免疫球蛋白 A（SIgA）、分泌型免疫球蛋白 M（SIgM）和 IgG。在怀孕期间接种流感和百日咳疫苗会诱导人乳中针对病原体的特异性 SIgA 和 IgG 反应，这些反应已被证明可保护母乳喂养的婴儿免受这些呼吸道疾病的侵害。此外，在怀孕期间和哺乳期接种的针对 SARS-CoV-2 病毒的 mRNA 疫苗会诱导人乳中针对 SARS-CoV-2 的 IgG 和 IgA 反应。本文综述了流感、百日咳和 COVID-19 疫苗通过人乳赋予的免疫益处。此外，还讨论了人乳免疫和改善哺乳期支持以满足公共卫生需求的未来研究方向。
