青藏高原麻花艽多糖的抗肿瘤潜力及结构表征
Antitumor Potential and Structure Characterization of Polysaccharides From Maxim in the Tibetan Plateau.
作者信息
Gong Ruixue, Cao Weiguo, Huang Haijun, Yu Bao, Chen Huan, Tao Wei, Luorong Quji, Luo Juan, Zhang Dan
机构信息
College of Traditional Chinese Medicine, Chongqing Medical University, Chongqing, China.
出版信息
Front Nutr. 2022 Jul 12;9:921892. doi: 10.3389/fnut.2022.921892. eCollection 2022.
This study purified two polysaccharides (LBMPs) from Maxim in several steps. The chemical structure of LBMP-2 was determined by HPGPC, FT-IR, IC, H and C NMR, AFM, SEM, and TEM. The results show that LBMP-2 was mainly composed of GalA, and the Mw of LBMP-2 is 23.799 kDa. In addition, the antioxidant activity, and the antitumor activity and were studied. LBMP-2 has excellent antioxidant and antitumor capacity. The inhibition of tumor cell proliferation may result in the inhibition of aerobic respiration and glycolysis. Tumor growth inhibition may inhibit the expression of AMPK in tumors and enhance spleen function. Compared with conventional chemotherapy drug cyclophosphamide, LBMP-2 is less harmful to the body and safer. Therefore, LBMP-2 provides a potential source of antitumor drugs.
本研究通过多个步骤从紫花地丁中纯化出两种多糖（LBMPs）。通过高效凝胶渗透色谱（HPGPC）、傅里叶变换红外光谱（FT-IR）、离子色谱（IC）、氢核磁共振（H NMR）和碳核磁共振（C NMR）、原子力显微镜（AFM）、扫描电子显微镜（SEM）和透射电子显微镜（TEM）确定了LBMP-2的化学结构。结果表明，LBMP-2主要由半乳糖醛酸（GalA）组成，其分子量为23.799 kDa。此外，还研究了其抗氧化活性和抗肿瘤活性。LBMP-2具有优异的抗氧化和抗肿瘤能力。对肿瘤细胞增殖的抑制可能导致有氧呼吸和糖酵解的抑制。肿瘤生长抑制可能会抑制肿瘤中腺苷酸活化蛋白激酶（AMPK）的表达并增强脾脏功能。与传统化疗药物环磷酰胺相比，LBMP-2对身体的危害较小且更安全。因此，LBMP-2提供了一种潜在的抗肿瘤药物来源。
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