一种源自链霉菌的新生物碱AM - 2282。分类学、发酵、分离及初步特性研究。
A new alkaloid AM-2282 OF Streptomyces origin. Taxonomy, fermentation, isolation and preliminary characterization.
作者信息
Omura S, Iwai Y, Hirano A, Nakagawa A, Awaya J, Tsuchya H, Takahashi Y, Masuma R
出版信息
J Antibiot (Tokyo). 1977 Apr;30(4):275-82. doi: 10.7164/antibiotics.30.275.
AM-2282, a new alkaloid has been isolated from cultures of Streptomyces sp. AM-2282 by solvent extraction and silica gel chromatography. The compound exhibits a strong absorption maximum at 292 nm and shows antimicrobial activity against fungi and yeast. The LD50 of its hydrochloride (i.p. in mice) is 6.6 mg/kg. The molecular formula of AM-2282 has been determined as C28H26N4O3. The producing strain, AM-2282 was classified as a new species and the name, Streptomyces staurosporeus AWAYA, TAKAHASHI and OMURA, nov. sp. is proposed.
AM - 2282是一种新的生物碱，已通过溶剂萃取和硅胶柱色谱法从链霉菌属菌株AM - 2282的培养物中分离出来。该化合物在292 nm处有一个很强的最大吸收峰，并对真菌和酵母表现出抗菌活性。其盐酸盐的半数致死量（小鼠腹腔注射）为6.6 mg/kg。AM - 2282的分子式已确定为C₂₈H₂₆N₄O₃。产生该生物碱的菌株AM - 2282被归类为一个新物种，并提出了新的名称，即星孢链霉菌阿瓦亚、高桥和大村种。
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