Wang Ya, Li Dandan, Jia Zijun, Hui Jiaqi, Xin Qiqi, Zhou Qingbing, Cong Weihong, Xu Fengqin
Institute of Geriatric, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Laboratory of Cardiovascular Diseases, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Front Cardiovasc Med. 2022 Jul 12;9:941607. doi: 10.3389/fcvm.2022.941607. eCollection 2022.
Emerging evidence has linked gut microbiota (GM) and its related metabolites to atherosclerosis (AS). This study aimed to analyze the evolution of GM in AS in the past decades, and provide valuable insights in this field.
Web of Science Core Collection (WoSCC) was applied to retrieve the publications related to GM in AS from their inception until 2 December 2021, and the data was analyzed in Microsoft Excel, Scimago Graphica, CiteSpace, and VOSviewer.
In total, 560 documents were extracted from the WoSCC databases. The publications have shown rapid growth since 2008. China and Cleveland Clin were the most prolific country and institution, respectively. The journal with the most publications is , and was the most co-cited journal. Among 3556 related authors, Hazen, Stanley L., Tang, W. H. Wilson, and Wang, Zeneng were the top 3 contributing authors in this field. Aside from "gut microbiota," "atherosclerosis," the terms "TMAO," "metabolite," "obesity," and "phosphatidylcholine" were frequently occurred in the abstract and title of articles. Burst detection of keywords indicated that "metabolic syndrome," "acid," and "bile acid" were hot topics in recent years. According to the co-citation analysis of references, the research focus in this area has changed over time, and recent researches focus on choline, hypertension, butyrate, and berberine.
Our study showed that the researches of GM in AS have been flourishing, and the content themes were constantly deepened. Human GM is critical to atherosclerotic diseases, and this hot topic is still worthy of more focus in the future.
新出现的证据表明肠道微生物群（GM）及其相关代谢产物与动脉粥样硬化（AS）有关。本研究旨在分析过去几十年中AS患者GM的演变情况，并为该领域提供有价值的见解。
应用科学网核心合集（WoSCC）检索从开始到2021年12月2日与AS中GM相关的出版物，并在Microsoft Excel、Scimago Graphica、CiteSpace和VOSviewer中对数据进行分析。
总共从WoSCC数据库中提取了560篇文献。自2008年以来，出版物数量呈快速增长。中国和克利夫兰诊所分别是发文量最多的国家和机构。发文量最多的期刊是 ，被引次数最多的期刊是 。在3556位相关作者中，哈森、斯坦利·L.、唐、W.H.威尔逊和王增能是该领域贡献最大的前三位作者。除了“肠道微生物群”“动脉粥样硬化”外，“氧化三甲胺”“代谢产物”“肥胖”和“磷脂酰胆碱”等术语也频繁出现在文章的摘要和标题中。关键词的突发检测表明，“代谢综合征”“酸”和“胆汁酸”是近年来的热门话题。根据参考文献的共被引分析，该领域的研究重点随时间发生了变化，近期的研究集中在胆碱、高血压、丁酸盐和黄连素上。
我们的研究表明，AS中GM的研究一直在蓬勃发展，内容主题也在不断深化。人体GM对动脉粥样硬化疾病至关重要，这个热门话题在未来仍值得更多关注。
