Department of Periodontology, Faculty of Dentistry, Inonu University, 44280, Malatya, Turkey.
Department of Periodontology, Karatekin University, Çankırı, Turkey.
Clin Oral Investig. 2022 Oct;26(10):6341-6346. doi: 10.1007/s00784-022-04588-6. Epub 2022 Jul 29.
Oral mucositis (OM) is a frequent complication of cancer treatments. Oral mucositis and periodontal disease have a common inflammatory pattern. The purpose of this study was to evaluate the OM and its association with periodontal status in patients with hematologic malignancies who undergo high-dose chemotherapy.
Fifty-five patients who received high-dose chemotherapy were included in the study. Full-mouth periodontal clinical measurements including plaque index (PI), gingival index (GI), clinical attachment level (CAL), and probing depth (PD) values were recorded before the condition chemotherapy regime. OM monitoring was initiated 1 day after the chemotherapy and maintained for 20 days.
Twenty-two of patients (40%) were observed oral mucositis after high-dose chemotherapy. Patients with mucositis had significantly higher GI scores than those who did not have mucositis (p < 0.05). There was a significantly moderate positive correlation between the grade of mucositis and GI scores (p < 0.05). In patients with periodontitis, the incidence of grade 1-2 mucositis was significantly higher than in the healthy group (p < 0.05). In individuals with periodontitis and gingivitis, the healing duration of mucositis was significantly longer than the healthy group (p < 0.05).
The results of this study showed that the severity grades of oral mucositis may increase in patients with gingival inflammation. The results also suggest that periodontal diseases may have a significant impact on the duration of oral mucositis.
The current study contributes to our understanding of the importance of oral health status in reducing the occurrence, severity, and duration of OM in hematological cancer patients treated with high-dose chemotherapy.
口腔黏膜炎（OM）是癌症治疗的常见并发症。口腔黏膜炎和牙周病具有共同的炎症模式。本研究旨在评估接受大剂量化疗的血液恶性肿瘤患者的 OM 及其与牙周状况的关系。
本研究纳入了 55 名接受大剂量化疗的患者。在化疗前记录了全口牙周临床测量指标，包括菌斑指数（PI）、牙龈指数（GI）、临床附着水平（CAL）和探诊深度（PD）值。在化疗后 1 天开始进行 OM 监测，持续 20 天。
22 名患者（40%）在接受大剂量化疗后出现口腔黏膜炎。患有黏膜炎的患者 GI 评分明显高于没有黏膜炎的患者（p<0.05）。黏膜炎的严重程度与 GI 评分之间存在显著的中度正相关（p<0.05）。在患有牙周炎的患者中，1-2 级黏膜炎的发生率明显高于健康组（p<0.05）。在患有牙周炎和牙龈炎的个体中，黏膜炎的愈合时间明显长于健康组（p<0.05）。
本研究结果表明，牙龈炎症患者的口腔黏膜炎严重程度可能会增加。结果还表明，牙周病可能会显著影响口腔黏膜炎的持续时间。
本研究有助于我们理解口腔健康状况在降低接受大剂量化疗的血液恶性肿瘤患者 OM 的发生、严重程度和持续时间方面的重要性。
