长链非编码RNA LINC00460在人类癌症中的致癌作用。
Oncogenic roles of the lncRNA LINC00460 in human cancers.
作者信息
Su Min, Tang Jinming, Yang Desong, Wu Zhining, Liao Qianjin, Wang Hui, Xiao Yuhang, Wang Wenxiang
机构信息
Thoracic Surgery Department 2, The Affiliated Cancer Hospital of Xiangya School of Medicine, Hunan Cancer Hospital, Central South University, Changsha, Hunan, 410013, People's Republic of China.
Hunan Clinical Medical Research Center of Accurate Diagnosis and Treatment for Esophageal Carcinoma, The Affiliated Cancer Hospital of Xiangya School of Medicine, Hunan Cancer Hospital, Central South University, Changsha, Hunan, 410013, People's Republic of China.
出版信息
Cancer Cell Int. 2022 Jul 29;22(1):240. doi: 10.1186/s12935-022-02655-2.
Long noncoding RNAs (lncRNAs) represent an important group of endogenous RNAs with limit protein-encoding capability, with a length of more than 200 nucleotides. Emerging evidence have demonstrated that lncRNAs are greatly involved in multiple cancers by playing critical roles in tumor initiation and progression. Long intergenic non-protein coding RNA 460 (LINC00460), a novel cancer-related lncRNA, exhibits abnormal expression and oncogenic function in multiple cancers, and positively correlates with poor clinical characteristics of cancer patients. LINC00460 has also been shown to be a promising biomarker for diagnosis as well as prognostic evaluation in cancer patients. In this review, we briefly summarized recent knowledge on the expression, functional roles, molecular mechanisms, and diagnostic and prognostic values of LINC00460 in human malignancies.
长链非编码RNA（lncRNAs）是一类重要的内源性RNA，其蛋白质编码能力有限，长度超过200个核苷酸。越来越多的证据表明，lncRNAs通过在肿瘤发生和发展中发挥关键作用，极大地参与了多种癌症。长链基因间非编码RNA 460（LINC00460）是一种新型的癌症相关lncRNA，在多种癌症中表现出异常表达和致癌功能，并且与癌症患者的不良临床特征呈正相关。LINC00460也已被证明是癌症患者诊断和预后评估的一个有前景的生物标志物。在这篇综述中，我们简要总结了关于LINC00460在人类恶性肿瘤中的表达、功能作用、分子机制以及诊断和预后价值的最新知识。
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