Department of Biomaterials and Cosmetics Chemistry, Faculty of Chemistry, Nicolaus Copernicus University in Torun, Gagarin 7 Street, 87-100 Torun, Poland; WellU sp.z.o.o, Wielkopolska 280, 81-531 Gdynia, Poland.
Department of Biomaterials and Cosmetics Chemistry, Faculty of Chemistry, Nicolaus Copernicus University in Torun, Gagarin 7 Street, 87-100 Torun, Poland.
Spectrochim Acta A Mol Biomol Spectrosc. 2022 Dec 5;282:121652. doi: 10.1016/j.saa.2022.121652. Epub 2022 Jul 21.
Fish skin collagen films are widely used as adhesives in medicine and cosmetology. Ultraviolet (UV) irradiation can be considered as an effective sterilization method for biomaterials, however, it may also lead to material photodegradation. In this work, the influence of xanthohumol and propanediol on the physico-chemical properties of collagen films before and after UV irradiation was studied. Collagen for this research was extracted from silver carp skin and thin films were fabricated by the solution casting methods. The structure of films was researched using infrared spectroscopy. The surface properties of films were investigated using Atomic Force Microscopy (AFM) and contact angle measurements. Mechanical properties were measured as well. It was found that the addition of xanthohumol and propanediol modified the roughness of collagen films and their mechanical properties. UV irradiation led to the water loss from the film and modification of the collagen structure. In the presence of propanediol and xanthohumol the water loss after UV irradiation was smaller than in UV-irradiated collagen films without these additives.
鱼皮胶原蛋白膜广泛应用于医学和化妆品领域，作为一种胶粘剂。紫外（UV）照射可以被认为是生物材料的一种有效灭菌方法，但也可能导致材料光降解。在这项工作中，研究了黄腐酚和 1,2-丙二醇对胶原蛋白膜在 UV 照射前后的物理化学性质的影响。用于本研究的胶原蛋白是从白鲢鱼皮中提取的，通过溶液浇铸法制备薄膜。使用红外光谱研究了薄膜的结构。使用原子力显微镜（AFM）和接触角测量研究了薄膜的表面性能。同时测量了机械性能。结果发现，黄腐酚和 1,2-丙二醇的添加改变了胶原蛋白膜的粗糙度及其机械性能。UV 照射导致薄膜失水和胶原蛋白结构的改变。在存在 1,2-丙二醇和黄腐酚的情况下，与没有这些添加剂的 UV 照射胶原蛋白膜相比，UV 照射后的失水较小。
