Tesoro Imaging S.L., 46022, Valencia, Spain.
Institute for Molecular Imaging and Instrumentation, Spanish National Research Council, 46022, Valencia, Spain.
Sci Rep. 2022 Jul 30;12(1):13147. doi: 10.1038/s41598-022-17472-w.
Mobile medical imaging devices are invaluable for clinical diagnostic purposes both in and outside healthcare institutions. Among the various imaging modalities, only a few are readily portable. Magnetic resonance imaging (MRI), the gold standard for numerous healthcare conditions, does not traditionally belong to this group. Recently, low-field MRI technology companies have demonstrated the first decisive steps towards portability within medical facilities and vehicles. However, these scanners' weight and dimensions are incompatible with more demanding use cases such as in remote and developing regions, sports facilities and events, medical and military camps, or home healthcare. Here we present in vivo images taken with a light, small footprint, low-field extremity MRI scanner outside the controlled environment provided by medical facilities. To demonstrate the true portability of the system and benchmark its performance in various relevant scenarios, we have acquired images of a volunteer's knee in: (i) an MRI physics laboratory; (ii) an office room; (iii) outside a campus building, connected to a nearby power outlet; (iv) in open air, powered from a small fuel-based generator; and (v) at the volunteer's home. All images have been acquired within clinically viable times, and signal-to-noise ratios and tissue contrast suffice for 2D and 3D reconstructions with diagnostic value. Furthermore, the volunteer carries a fixation metallic implant screwed to the femur, which leads to strong artifacts in standard clinical systems but appears sharp in our low-field acquisitions. Altogether, this work opens a path towards highly accessible MRI under circumstances previously unrealistic.
移动医疗成像设备在医疗机构内外的临床诊断中都具有不可估量的价值。在各种成像方式中,只有少数几种易于携带。磁共振成像(MRI)是许多医疗条件的金标准,但传统上不属于这一类。最近,低场 MRI 技术公司已经在医疗设施和车辆内实现了便携性的初步突破。然而,这些扫描仪的重量和尺寸与更苛刻的应用场景不兼容,例如在偏远和发展中地区、体育设施和活动、医疗和军事营地或家庭医疗保健中。在这里,我们展示了在医疗设施提供的受控环境之外,使用轻便、占地面积小、低场四肢 MRI 扫描仪进行的体内成像。为了展示系统的真正便携性,并在各种相关场景中对其性能进行基准测试,我们已经在志愿者的膝盖上获取了以下几种情况下的图像:(i)在 MRI 物理实验室;(ii)在办公室;(iii)在校园建筑外,连接到附近的电源插座;(iv)在户外,由小型燃料发电机供电;以及(v)在志愿者的家中。所有图像均在可行的临床时间内获取,并且信号噪声比和组织对比度足以进行具有诊断价值的 2D 和 3D 重建。此外,志愿者携带固定在股骨上的金属植入物,这会导致标准临床系统中出现强烈的伪影,但在我们的低场采集中则显得清晰锐利。总之,这项工作为以前不切实际的情况下实现高度可及的 MRI 开辟了道路。