Intravenous vitamin C in adults with sepsis in the intensive care unit: still LOV'IT?
作者信息
Stoppe Christian, Preiser Jean-Charles, de Backer Daniel, Elke Gunnar
机构信息
Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital Wuerzburg, Josef-Schneider-Straße 2, 97080, Wuerzburg, Germany.
Medical Direction, Erasme University Hospital, Universtié Libre de Bruxelles, Brussels, Belgium.
出版信息
Crit Care. 2022 Jul 30;26(1):230. doi: 10.1186/s13054-022-04106-w.
Abstract
摘要
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本文引用的文献
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Parenteral Vitamin C in Patients with Severe Infection: A Systematic Review.静脉注射维生素 C 治疗重症感染患者的系统评价
NEJM Evid. 2022 Sep;1(9):EVIDoa2200105. doi: 10.1056/EVIDoa2200105. Epub 2022 Jun 15.
2
Redefining critical illness.重新定义危重症。
Nat Med. 2022 Jun;28(6):1141-1148. doi: 10.1038/s41591-022-01843-x. Epub 2022 Jun 17.
3
Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit.重症监护室脓毒症成人患者的静脉内维生素 C。
N Engl J Med. 2022 Jun 23;386(25):2387-2398. doi: 10.1056/NEJMoa2200644. Epub 2022 Jun 15.
4
Wacker et al, Who Conclude That Vitamin C Monotherapy Failed to Significantly Reduce Mortality in Septic Shock Patients: Beware of Potential Confounding Factors!
Crit Care Med. 2022 Jun 1;50(6):e611-e612. doi: 10.1097/CCM.0000000000005516. Epub 2022 May 19.
5
The potential role of intravenous vitamin C monotherapy in critical illness.静脉注射维生素C单一疗法在危重症中的潜在作用。
JPEN J Parenter Enteral Nutr. 2022 Jul;46(5):972-976. doi: 10.1002/jpen.2338. Epub 2022 Feb 13.
6
Severe immunosuppression and not a cytokine storm characterizes COVID-19 infections.严重的免疫抑制，而非细胞因子风暴，是 COVID-19 感染的特征。
JCI Insight. 2020 Sep 3;5(17):140329. doi: 10.1172/jci.insight.140329.
7
Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and Severe Acute Respiratory Failure: The CITRIS-ALI Randomized Clinical Trial.维生素 C 输注对脓毒症和严重急性呼吸衰竭患者器官衰竭及炎症和血管损伤生物标志物的影响：CITRIS-ALI 随机临床试验。
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8
Derivation, Validation, and Potential Treatment Implications of Novel Clinical Phenotypes for Sepsis.新型败血症临床表型的推导、验证及潜在治疗意义。
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9
Hypovitaminosis C and vitamin C deficiency in critically ill patients despite recommended enteral and parenteral intakes.危重症患者尽管推荐了肠内和肠外摄入，但仍存在维生素 C 缺乏和 Hypovitaminosis C。
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Food for thought: why does the medical community struggle with research about nutritional therapy in the acute care setting?值得思考的问题：为何医学界在急性护理环境下的营养治疗研究方面存在困难？
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