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Intravenous vitamin C in adults with sepsis in the intensive care unit: still LOV'IT?重症监护病房中成年脓毒症患者静脉注射维生素C：仍值得“爱它”吗？
Crit Care. 2022 Jul 30;26(1):230. doi: 10.1186/s13054-022-04106-w.
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Intravenous vitamin C harmful in adults with sepsis.
J Paediatr Child Health. 2022 Aug;58(8):1488. doi: 10.1111/jpc.16113. Epub 2022 Jul 8.
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The Emerging Role of Vitamin C as a Treatment for Sepsis.维生素 C 在败血症治疗中的新作用。
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Accuracy of Point-of-Care Blood Glucose Level Measurements in Critically Ill Patients with Sepsis Receiving High-Dose Intravenous Vitamin C.危重病脓毒症患者接受大剂量静脉注射维生素 C 时即时血糖水平测量的准确性。
Pharmacotherapy. 2018 Nov;38(11):1155-1161. doi: 10.1002/phar.2182. Epub 2018 Oct 16.
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Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and Severe Acute Respiratory Failure: The CITRIS-ALI Randomized Clinical Trial.维生素 C 输注对脓毒症和严重急性呼吸衰竭患者器官衰竭及炎症和血管损伤生物标志物的影响：CITRIS-ALI 随机临床试验。
JAMA. 2019 Oct 1;322(13):1261-1270. doi: 10.1001/jama.2019.11825.
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Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial.维生素 C、硫胺素和氢化可的松对败血症患者呼吸机和血管加压素无使用天数的影响：VICTAS 随机临床试验。
JAMA. 2021 Feb 23;325(8):742-750. doi: 10.1001/jama.2020.24505.
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Vitamin C for the treatment of sepsis: The scientific rationale.维生素 C 治疗脓毒症：科学依据。
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Emerging Adjunctive Approach for the Treatment of Sepsis: Vitamin C and Thiamine.脓毒症治疗的新兴辅助方法：维生素C和硫胺素
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Effect of Vitamin C, Hydrocortisone, and Thiamine vs Hydrocortisone Alone on Time Alive and Free of Vasopressor Support Among Patients With Septic Shock: The VITAMINS Randomized Clinical Trial.维生素 C、氢化可的松和硫胺素与单独使用氢化可的松对感染性休克患者存活时间和脱离血管加压支持的影响：VITAMINS 随机临床试验。
JAMA. 2020 Feb 4;323(5):423-431. doi: 10.1001/jama.2019.22176.

引用本文的文献

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What do we know about micronutrients in critically ill patients? A narrative review.关于危重症患者的微量营养素，我们了解多少？一篇叙述性综述。
JPEN J Parenter Enteral Nutr. 2025 Jan;49(1):33-58. doi: 10.1002/jpen.2700. Epub 2024 Nov 18.
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Current perspectives in the management of sepsis and septic shock.脓毒症和感染性休克管理的当前观点
Front Med (Lausanne). 2024 Aug 15;11:1431791. doi: 10.3389/fmed.2024.1431791. eCollection 2024.
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Vitamin C deficiency in critically ill COVID-19 patients admitted to intensive care unit.入住重症监护病房的危重症 COVID-19 患者的维生素 C 缺乏情况。
Front Med (Lausanne). 2023 Dec 20;10:1301001. doi: 10.3389/fmed.2023.1301001. eCollection 2023.
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Effect of high-dose intravenous ascorbic acid on microcirculation and endothelial glycocalyx during sepsis and septic shock: a double-blind, randomized, placebo-controlled study.大剂量静脉注射抗坏血酸对脓毒症和脓毒性休克期间微循环和内皮糖萼的影响：一项双盲、随机、安慰剂对照研究。
BMC Anesthesiol. 2023 Sep 12;23(1):309. doi: 10.1186/s12871-023-02265-z.
5
[Immunomodulation by nutritional intervention in critically ill patients].[危重症患者营养干预的免疫调节作用]
Anaesthesiologie. 2023 Apr;72(4):229-244. doi: 10.1007/s00101-023-01258-4. Epub 2023 Feb 16.
6
An update of the effects of vitamins D and C in critical illness.维生素D和C在危重症中的作用的最新进展。
Front Med (Lausanne). 2023 Jan 11;9:1083760. doi: 10.3389/fmed.2022.1083760. eCollection 2022.

本文引用的文献

1
Parenteral Vitamin C in Patients with Severe Infection: A Systematic Review.静脉注射维生素 C 治疗重症感染患者的系统评价
NEJM Evid. 2022 Sep;1(9):EVIDoa2200105. doi: 10.1056/EVIDoa2200105. Epub 2022 Jun 15.
2
Redefining critical illness.重新定义危重症。
Nat Med. 2022 Jun;28(6):1141-1148. doi: 10.1038/s41591-022-01843-x. Epub 2022 Jun 17.
3
Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit.重症监护室脓毒症成人患者的静脉内维生素 C。
N Engl J Med. 2022 Jun 23;386(25):2387-2398. doi: 10.1056/NEJMoa2200644. Epub 2022 Jun 15.
4
Wacker et al, Who Conclude That Vitamin C Monotherapy Failed to Significantly Reduce Mortality in Septic Shock Patients: Beware of Potential Confounding Factors!
Crit Care Med. 2022 Jun 1;50(6):e611-e612. doi: 10.1097/CCM.0000000000005516. Epub 2022 May 19.
5
The potential role of intravenous vitamin C monotherapy in critical illness.静脉注射维生素C单一疗法在危重症中的潜在作用。
JPEN J Parenter Enteral Nutr. 2022 Jul;46(5):972-976. doi: 10.1002/jpen.2338. Epub 2022 Feb 13.
6
Severe immunosuppression and not a cytokine storm characterizes COVID-19 infections.严重的免疫抑制，而非细胞因子风暴，是 COVID-19 感染的特征。
JCI Insight. 2020 Sep 3;5(17):140329. doi: 10.1172/jci.insight.140329.
7
Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and Severe Acute Respiratory Failure: The CITRIS-ALI Randomized Clinical Trial.维生素 C 输注对脓毒症和严重急性呼吸衰竭患者器官衰竭及炎症和血管损伤生物标志物的影响：CITRIS-ALI 随机临床试验。
JAMA. 2019 Oct 1;322(13):1261-1270. doi: 10.1001/jama.2019.11825.
8
Derivation, Validation, and Potential Treatment Implications of Novel Clinical Phenotypes for Sepsis.新型败血症临床表型的推导、验证及潜在治疗意义。
JAMA. 2019 May 28;321(20):2003-2017. doi: 10.1001/jama.2019.5791.
9
Hypovitaminosis C and vitamin C deficiency in critically ill patients despite recommended enteral and parenteral intakes.危重症患者尽管推荐了肠内和肠外摄入，但仍存在维生素 C 缺乏和 Hypovitaminosis C。
Crit Care. 2017 Dec 11;21(1):300. doi: 10.1186/s13054-017-1891-y.
10
Food for thought: why does the medical community struggle with research about nutritional therapy in the acute care setting?值得思考的问题：为何医学界在急性护理环境下的营养治疗研究方面存在困难？
BMC Med. 2017 Feb 24;15(1):38. doi: 10.1186/s12916-017-0812-x.

Intravenous vitamin C in adults with sepsis in the intensive care unit: still LOV'IT?

作者信息

Stoppe Christian, Preiser Jean-Charles, de Backer Daniel, Elke Gunnar

机构信息

Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital Wuerzburg, Josef-Schneider-Straße 2, 97080, Wuerzburg, Germany.

Medical Direction, Erasme University Hospital, Universtié Libre de Bruxelles, Brussels, Belgium.

出版信息

Crit Care. 2022 Jul 30;26(1):230. doi: 10.1186/s13054-022-04106-w.

DOI:10.1186/s13054-022-04106-w
PMID:35908003
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9339181/
Abstract
摘要