• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

[危重症患者营养干预的免疫调节作用]

[Immunomodulation by nutritional intervention in critically ill patients].

作者信息

Hirschberger Simon, Schmid Annika, Kreth Simone

机构信息

Klinik für Anaesthesiologie, LMU Klinikum München, München, Deutschland.

Walter-Brendel-Zentrum für experimentelle Medizin, Ludwig-Maximilians-Universität München (LMU), Marchioninistr. 68, 81377, München, Deutschland.

出版信息

Anaesthesiologie. 2023 Apr;72(4):229-244. doi: 10.1007/s00101-023-01258-4. Epub 2023 Feb 16.

DOI:10.1007/s00101-023-01258-4
PMID:36797533
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9934515/
Abstract

Critically ill patients often suffer from a complex and severe immunological dysfunction. The differentiation and function of human immune cells are fundamentally controlled through metabolic processes. New concepts of immunonutrition therefore try to use enteral and parenteral nutrition to positively impact on the immune function of intensive care unit patients. This review article concisely presents the currently available evidence on the commonly used isolated supplements (anti-oxidative substances, amino acids, essential fatty acids) and difficulties related to their clinical use. The second part presents new and more comprehensive concepts of immunonutrition to influence the intestinal microbiome and to modulate the macronutrient composition. Immunonutrition of critically ill patients bears enormous potential and could become a valuable clinical tool for modulation of the immunometabolism of intensive care unit patients.

摘要

重症患者常伴有复杂且严重的免疫功能障碍。人类免疫细胞的分化和功能从根本上受代谢过程控制。因此，免疫营养的新概念试图通过肠内和肠外营养对重症监护病房患者的免疫功能产生积极影响。这篇综述文章简要介绍了目前关于常用单一补充剂（抗氧化物质、氨基酸、必需脂肪酸）的现有证据以及与其临床应用相关的困难。第二部分介绍了影响肠道微生物群和调节常量营养素组成的免疫营养新的、更全面的概念。重症患者的免疫营养具有巨大潜力，可能成为调节重症监护病房患者免疫代谢的有价值的临床工具。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/564b/10076418/9b6c7eaa44ec/101_2023_1258_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/564b/10076418/5968e1bf71b3/101_2023_1258_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/564b/10076418/fcf2cf5d5631/101_2023_1258_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/564b/10076418/9b6c7eaa44ec/101_2023_1258_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/564b/10076418/5968e1bf71b3/101_2023_1258_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/564b/10076418/fcf2cf5d5631/101_2023_1258_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/564b/10076418/9b6c7eaa44ec/101_2023_1258_Fig3_HTML.jpg

相似文献

1
[Immunomodulation by nutritional intervention in critically ill patients].[危重症患者营养干预的免疫调节作用]
Anaesthesiologie. 2023 Apr;72(4):229-244. doi: 10.1007/s00101-023-01258-4. Epub 2023 Feb 16.
2
Feeding the critically ill obese patient: a systematic review protocol.为危重症肥胖患者提供营养支持：一项系统评价方案
JBI Database System Rev Implement Rep. 2015 Oct;13(10):95-109. doi: 10.11124/jbisrir-2015-2458.
3
Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Pediatric Critically Ill Patient: Society of Critical Care Medicine and American Society for Parenteral and Enteral Nutrition.儿童危重症患者营养支持治疗提供和评估指南：重症医学学会和肠外与肠内营养学会。
JPEN J Parenter Enteral Nutr. 2017 Jul;41(5):706-742. doi: 10.1177/0148607117711387. Epub 2017 Jun 2.
4
Should immunonutrition become routine in critically ill patients? A systematic review of the evidence.免疫营养是否应成为重症患者的常规治疗？证据的系统评价。
JAMA. 2001;286(8):944-53. doi: 10.1001/jama.286.8.944.
5
Nutrition of the critically ill patient and effects of implementing a nutritional support algorithm in ICU.重症患者的营养及在重症监护病房实施营养支持算法的效果。
J Clin Nurs. 2006 Feb;15(2):168-77. doi: 10.1111/j.1365-2702.2006.01262.x.
6
Canadian clinical practice guidelines for nutrition support in mechanically ventilated, critically ill adult patients.加拿大机械通气的危重症成年患者营养支持临床实践指南。
JPEN J Parenter Enteral Nutr. 2003 Sep-Oct;27(5):355-73. doi: 10.1177/0148607103027005355.
7
Hypovitaminosis C and vitamin C deficiency in critically ill patients despite recommended enteral and parenteral intakes.危重症患者尽管推荐了肠内和肠外摄入，但仍存在维生素 C 缺乏和 Hypovitaminosis C。
Crit Care. 2017 Dec 11;21(1):300. doi: 10.1186/s13054-017-1891-y.
8
Immunonutrition in Critical Illness: What Is the Role?危重症患者的免疫营养：作用是什么？
Nutr Clin Pract. 2018 Jun;33(3):348-358. doi: 10.1002/ncp.10102.
9
Supplemental parenteral nutrition in critically ill patients: a study protocol for a phase II randomised controlled trial.危重症患者的补充肠外营养：一项II期随机对照试验的研究方案
Trials. 2015 Dec 24;16:587. doi: 10.1186/s13063-015-1118-y.
10
Immunonutrition in the critically ill: a systematic review of clinical outcome.危重症患者的免疫营养：临床结局的系统评价
Crit Care Med. 1999 Dec;27(12):2799-805. doi: 10.1097/00003246-199912000-00032.

引用本文的文献

1
A Narrative Review: Analysis of Supplemental Parenteral Nutrition in Adults at the End of Life.一篇叙述性综述：对临终成年患者补充肠外营养的分析
Pharmaceuticals (Basel). 2023 Dec 30;17(1):65. doi: 10.3390/ph17010065.
2
[Immunonutrition-In search of the optimum].[免疫营养——探寻最佳方案]
Anaesthesiologie. 2023 Apr;72(4):227-228. doi: 10.1007/s00101-023-01276-2. Epub 2023 Apr 5.

本文引用的文献

1
Association between caloric adequacy and short-term clinical outcomes in critically ill patients using a weight-based equation: Secondary analysis of a cluster-randomized controlled trial.使用基于体重的公式评估危重症患者热量充足与短期临床结局之间的关联：一项整群随机对照试验的二次分析
Front Nutr. 2022 Sep 2;9:902986. doi: 10.3389/fnut.2022.902986. eCollection 2022.
2
A Randomized Trial of Enteral Glutamine for Treatment of Burn Injuries.肠内给予谷氨酰胺治疗烧伤随机临床试验。
N Engl J Med. 2022 Sep 15;387(11):1001-1010. doi: 10.1056/NEJMoa2203364. Epub 2022 Sep 9.
3
The effect of intravenous vitamin C on clinical outcomes in patients with sepsis or septic shock: A meta-analysis of randomized controlled trials.
静脉注射维生素C对脓毒症或脓毒性休克患者临床结局的影响：一项随机对照试验的荟萃分析。
Front Nutr. 2022 Jul 28;9:964484. doi: 10.3389/fnut.2022.964484. eCollection 2022.
4
Vitamin C in sepsis.脓毒症中的维生素C
Intensive Care Med. 2022 Nov;48(11):1621-1624. doi: 10.1007/s00134-022-06822-x. Epub 2022 Aug 12.
5
Restrictive fluid therapy and high-dose vitamin C in sepsis.脓毒症患者的限制液体疗法和大剂量维生素 C 治疗。
Nat Rev Nephrol. 2022 Oct;18(10):607-608. doi: 10.1038/s41581-022-00609-5.
6
Intravenous vitamin C in adults with sepsis in the intensive care unit: still LOV'IT?重症监护病房中成年脓毒症患者静脉注射维生素C：仍值得“爱它”吗？
Crit Care. 2022 Jul 30;26(1):230. doi: 10.1186/s13054-022-04106-w.
7
Impaired ketogenesis ties metabolism to T cell dysfunction in COVID-19.在 COVID-19 中，酮生成受损将代谢与 T 细胞功能障碍联系起来。
Nature. 2022 Sep;609(7928):801-807. doi: 10.1038/s41586-022-05128-8. Epub 2022 Jul 28.
8
Ketone Bodies Improve Human CD8 Cytotoxic T-Cell Immune Response During COVID-19 Infection.酮体可改善新冠病毒感染期间人类CD8细胞毒性T细胞免疫反应。
Front Med (Lausanne). 2022 Jun 16;9:923502. doi: 10.3389/fmed.2022.923502. eCollection 2022.
9
Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit.重症监护室脓毒症成人患者的静脉内维生素 C。
N Engl J Med. 2022 Jun 23;386(25):2387-2398. doi: 10.1056/NEJMoa2200644. Epub 2022 Jun 15.
10
Probiotics in Critical Illness: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.益生菌在危重病中的应用：一项随机对照试验的系统评价和荟萃分析。
Crit Care Med. 2022 Aug 1;50(8):1175-1186. doi: 10.1097/CCM.0000000000005580. Epub 2022 May 25.