California Medical Innovations Institute, 11107 Roselle St., San Diego, CA, 92121, USA.
3DT, San Diego, CA, USA.
Biomech Model Mechanobiol. 2022 Oct;21(5):1613-1621. doi: 10.1007/s10237-022-01610-4. Epub 2022 Jul 30.
Fecobionics is an integrated device that has shown promise for assessment of anorectal function. We used a wireless Fecobionics prototype to visualize defecatory patterns and to compute volume-pressure, contraction work, and flow. Twelve normal subjects were studied. The probe was 10 cm-long and contained pressure sensors and electrodes for impedance planimetry. Pressures, diameters, and volume data during defecation were analyzed. The bag was distended inside rectum to the urge-to-defecate level where after the subjects were asked to evacuate. The contraction work and defecatory flow were computed from the volume changes during expulsion. The minimum anal diameter during the evacuation was 17.6 ± 1.5 mm. The middle diameter recording was 10-20% lower than the front diameter channels and 10-20% bigger than the rear channels. The bag volume at urge correlated with the minimum diameter (r = 0.63). The diameter-pressure and volume-pressure loops were counterclockwise with phases of bag filling, isometric contraction, ejection and anal passage. The defecatory contraction work was 3520 ± 480 mL × cmHO. The maximum flow during defecation was 302 ± 33 mL/s. The flow was associated with the anal diameter (r = 0.84) but not with the rectoanal pressure gradient (r = 0.14). Volume-pressure loops have a tremendous impact on the understanding of cardiopulmonary pathophysiology. Future studies will shed light on potential clinical impact in defecatory pathophysiology.
Fecobionics 是一种集成设备，已显示出评估肛肠功能的潜力。我们使用无线 Fecobionics 原型来可视化排便模式，并计算容量-压力、收缩功和流量。对 12 名正常受试者进行了研究。探头长 10 厘米，包含压力传感器和用于阻抗平面测量的电极。分析了排便过程中的压力、直径和体积数据。球囊在直肠内膨胀至便意水平，然后要求受试者排空。从排空过程中的体积变化计算收缩功和排便流量。排空时最小肛管直径为 17.6 ± 1.5 毫米。中间直径记录比前直径通道低 10-20%，比后直径通道大 10-20%。在便意时的球囊体积与最小直径相关（r=0.63）。直径-压力和体积-压力环呈逆时针方向，包括球囊充盈、等长收缩、排空和肛门通道。排便收缩功为 3520±480mL×cmHO。排便时最大流量为 302±33mL/s。流量与肛管直径相关（r=0.84），但与直肠肛管压力梯度无关（r=0.14）。体积-压力环对心肺病理生理学的理解有重大影响。未来的研究将揭示在排便病理生理学方面的潜在临床影响。
