Department of Geriatrics/Radboud Alzheimer Center, Radboud Institute for Health Sciences, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6500 HB Nijmegen, the Netherlands.
Department of Physiology, Radboud Institute for Health Sciences, Radboud University Medical Center, Philips van Leydenlaan 15, 6500 HB Nijmegen, the Netherlands.
Neurosci Biobehav Rev. 2022 Sep;140:104802. doi: 10.1016/j.neubiorev.2022.104802. Epub 2022 Jul 28.
Sedentary behaviour may increase the risk of dementia. Studying physiological effects of sedentary behaviour on cerebral health may provide new insights into the nature of this association. Accordingly, we reviewed if and how acute and habitual sedentary behaviour relate to brain health factors in middle-aged and older adults (≥45 years). Four databases were searched. Twenty-nine studies were included, with mainly cross-sectional designs. Nine studies examined neurotrophic factors and six studied functional brain measures, with the majority of these studies finding no associations with sedentary behaviour. The results from studies on sedentary behaviour and cerebrovascular measures were inconclusive. There was a tentative association between habitual sedentary behaviour and structural white matter health. An explanatory pathway for this effect might relate to the immediate vascular effects of sitting, such as elevation of blood pressure. Nevertheless, due to the foremost cross-sectional nature of the available evidence, reverse causality could also be a possible explanation. More prospective studies are needed to understand the potential of sedentary behaviour as a target for brain health.
久坐行为可能会增加痴呆的风险。研究久坐行为对大脑健康的生理影响可能为理解这种关联的本质提供新的视角。因此，我们综述了中年及以上（≥45 岁）人群中急性和习惯性久坐行为与大脑健康因素的关系。我们检索了四个数据库。纳入了 29 项研究，主要为横断面设计。9 项研究检测了神经营养因子，6 项研究检测了功能性大脑指标，其中大多数研究发现久坐行为与这些指标无关联。关于久坐行为和脑血管指标的研究结果尚无定论。习惯性久坐行为与结构白质健康之间存在初步关联。这种关联的可能机制与坐姿导致的即时血管效应有关，如血压升高。然而，由于现有证据主要为横断面研究，因此也可能存在反向因果关系。需要更多前瞻性研究来了解久坐行为作为大脑健康靶点的潜力。
