洋蓟叶提取物介导的对雄性大鼠黄曲霉毒素作用的神经保护作用。
Artichoke Leaf Extract-Mediated Neuroprotection against Effects of Aflatoxin in Male Rats.
机构信息
Department of Environmental Studies, Institute of Graduate Studies and Research, Alexandria University, Egypt.
Bioscreening and Preclinical Trial Lab, Biochemistry Department, Faculty of Science, Alexandria University, Egypt.
出版信息
Biomed Res Int. 2022 Jul 19;2022:4421828. doi: 10.1155/2022/4421828. eCollection 2022.
Attenuation of adverse effects of aflatoxin (AFB) in brains of B rats by extracts of leaves of artichoke was studied. The active ingredients in extracts of leaves of artichoke, L., were determined by HPLC analysis. In the 42-day experiment, rats were exposed to either sterile water, 4% DMSO, 100 mg artichoke leaf extract/kg body mass, 72 g aflatoxin B/kg body mass, or AFB plus artichoke leaf extract. Neurotoxicity of AFB was determined by an increase in profile of lipids, augmentation of plasmatic glucose and concentrations of insulin, oxidative stress, increased activities of cholinergic enzymes, and a decrease in activities of several antioxidant enzymes and pathological changes in brain tissue. Extracts of artichoke leaf significantly reduced adverse effects caused by AFB, rescuing most of the parameters to values similar to unexposed controls, which demonstrated that adverse, neurotoxic effects caused by aflatoxin B could be significantly reduced by simultaneous dietary supplementation with artichoke leaf extract, which itself is not toxic.
研究了朝鲜蓟叶提取物对 B 型大鼠脑中黄曲霉毒素（AFB）不良影响的衰减作用。通过 HPLC 分析确定了朝鲜蓟叶提取物中的活性成分。在为期 42 天的实验中，大鼠分别暴露于无菌水、4% DMSO、100mg 朝鲜蓟叶提取物/kg 体重、72g 黄曲霉毒素 B/kg 体重或 AFB 加朝鲜蓟叶提取物。AFB 的神经毒性通过脂质谱的增加、血浆葡萄糖和胰岛素浓度的增加、氧化应激、胆碱能酶活性的增加以及几种抗氧化酶活性的降低以及脑组织的病理变化来确定。朝鲜蓟叶提取物可显著减轻 AFB 引起的不良反应，使大多数参数恢复到未暴露对照值，这表明黄曲霉毒素 B 引起的不良神经毒性作用可通过同时饮食补充朝鲜蓟叶提取物显著降低，而朝鲜蓟叶提取物本身并无毒性。
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