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富含透明质酸的富血小板血浆在皮肤伤口中的应用研究——宏观结果

Study on the Application of PRP Enriched with Hyaluronic Acid to Skin Wounds-Macroscopic Result.

作者信息

Marinescu Elena-Alexandra, Nica Oliviu, Parvanescu Vlad, Mercut Razvan, Marinescu Daniela, Cojocaru Anca, Georgescu Milena, Ciurea Marius

机构信息

Departament of Plastic Surgery, University of Medicine and Pharmacy of Craiova, Romania.

General Surgery Clinic No. 1, Craiova Emergency Clinical Hospital, Romania.

出版信息

Curr Health Sci J. 2022 Jan-Mar;48(1):44-50. doi: 10.12865/CHSJ.48.01.06. Epub 2022 Mar 31.

DOI:10.12865/CHSJ.48.01.06
PMID:35911941
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9289591/
Abstract

Tissue healing is a complex process of replacing damaged tissue structures, being a dynamic process with spatial and temporal involvement. In practice, there are three types of healing: primary, secondary and tertiary. Since even tertiary healing can cause different problems depending on the individual patient, the medical world has always strived for new, easier, more effective, faster, and low cost-effective methods to cover skin wounds. This experiment aims to find a method that is as efficient and fast as possible, with minimal costs, of native healing of skin wounds and the development of a protocol that is as reliable and safe as possible for the patient. The experiment was carried out within the animal facility of the University of Medicine and Pharmacy of Craiova, with the agreement of our institutional Ethics Committee. The experimental group consisted of 30 individuals (Wistar laboratory rats), clinically healthy, male and female, being divided into 3 sublots of 10 individuals each. Each sublot was sacrificed at different time intervals: 7, 14 and 21 days, respectively. The local evolution of each individual was monitored during the experimental days, as well as their general state of health. Before slaughter, the lesions were examined macroscopically, following their size, whether or not the infection was present and the presence of other self-inflicted lesions later. Macroscopically, a faster wound healing was found where PRP enriched with hyaluronic acid was applied from the 7th day, so we can say that at first glance the "free" healing period in the case of enhanced epithelialization was about 7 days shorten. This fact will be confirmed or refuted following histopathological examinations and immunohistochemistry.

摘要

组织愈合是一个复杂的过程，用于替换受损的组织结构，是一个涉及空间和时间的动态过程。在实践中，有三种愈合类型：一期愈合、二期愈合和三期愈合。由于即使是三期愈合也可能因个体患者而导致不同问题，医学界一直在努力寻找新的、更简便、更有效、更快且成本效益高的方法来覆盖皮肤伤口。本实验旨在找到一种尽可能高效、快速且成本最低的皮肤伤口自然愈合方法，并制定一种对患者尽可能可靠和安全的方案。该实验在克拉约瓦医科药科大学的动物设施内进行，并获得了我们机构伦理委员会的批准。实验组由30只个体（Wistar实验大鼠）组成，临床健康，有雄性和雌性，分为3个小组，每组10只。每个小组在不同的时间间隔（分别为7天、14天和21天）被处死。在实验期间监测每个个体的局部变化以及它们的总体健康状况。在宰杀前，对病变进行宏观检查，观察其大小、是否存在感染以及后期是否存在其他自伤性病变。宏观上，从第7天开始应用富含透明质酸的富血小板血浆（PRP）的部位伤口愈合更快，所以我们可以说，乍一看，在增强上皮化的情况下，“自由”愈合期缩短了约7天。这一事实将在组织病理学检查和免疫组织化学检查后得到证实或反驳。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3774/9289591/c3e47a152e2c/CHSJ-48-01-44-fig18.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3774/9289591/9896c6db6f9d/CHSJ-48-01-44-fig1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3774/9289591/dfbac33b6772/CHSJ-48-01-44-fig10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3774/9289591/978b85834554/CHSJ-48-01-44-fig11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3774/9289591/f52b58257aff/CHSJ-48-01-44-fig12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3774/9289591/9dd0131c2ba2/CHSJ-48-01-44-fig13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3774/9289591/14f7db66ff94/CHSJ-48-01-44-fig14.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3774/9289591/be89b8235f3e/CHSJ-48-01-44-fig15.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3774/9289591/26616edb3243/CHSJ-48-01-44-fig16.jpg
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2
The Three-Dimensional Structure of Porcine Bladder Scaffolds Alters the Biology of Murine Diabetic Wound Healing.猪膀胱支架的三维结构改变了小鼠糖尿病创面愈合的生物学特性。
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3
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5
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6
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