24 小时尿钾排泄与一般人群的睡眠质量呈负相关，与睡眠呼吸障碍无关。
24-hour urinary potassium excretion is negatively associated with self-reported sleep quality in the general population, independently of sleep-disordered breathing.
机构信息
Hypertension Center of People's Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Hypertension Institute, National Health Committee Key Laboratory of Hypertension Clinical Research, Key Laboratory of Xinjiang Uygur Autonomous Region, Hypertension Research Laboratory, Xinjiang Clinical Medical Research Center for Hypertension (Cardio-Cerebrovascular) Diseases, Urumqi, Xinjiang China.
出版信息
J Clin Sleep Med. 2022 Nov 1;18(11):2589-2596. doi: 10.5664/jcsm.10168.
STUDY OBJECTIVES
To investigate the association of 24-hour urinary potassium excretion with self-reported sleep quality in the general population.
METHODS
In this cross-sectional study, a population of patients aged 18 years or older was randomly selected from Xinjiang, China in 2019, 24-hour urine samples collected, and Pittsburgh Sleep Quality Index (PSQI) questionnaires assessed. Participants were divided into 2 groups (upper and lower median of 24-hour urinary potassium excretion). Poor sleep quality was defined as PSQI global score ≥ 6. Associations between 24-hour urinary potassium excretion and [24.8 mmol/L] sleep quality were assessed by multiple logistic regression analysis in total participants and those stratified by sex.
RESULTS
In total, 24-hour urine samples were collected from 1,147 participants, of whom data for those with complete urine samples and PSQI data were analyzed (n = 727; mean age = 48.7 years; percentage of women = 62%). Compared with the upper median group for 24-hour urinary potassium excretion, the lower median group showed a significantly higher PSQI global score (6 vs 5, = .011), and prevalence of poor sleep quality (51.7% vs 42.2%, = .011). In a fully-adjusted model of multivariate logistic regression, the lower median group showed 1.50-fold increased odds for presence of poor sleep quality (95% confidence interval: 1.01-2.24, = .045). Sex-specific analyses translated these results to women, but not to men.
CONCLUSIONS
These results suggest that low potassium intake, indicated by lower potassium excretion, is associated with poor sleep quality in the general population, especially among women. Therefore, additional research is necessary to clarify the effect of increasing potassium intake to improve sleep quality.
CITATION
Li M, Heizhati M, Wang L, et al. 24-hour urinary potassium excretion is negatively associated with self-reported sleep quality in the general population, independently of sleep-disordered breathing. . 2022;18(11):2589-2596.
研究目的
调查普通人群 24 小时尿钾排泄与自我报告的睡眠质量之间的关系。
方法
在这项横断面研究中，2019 年从中国新疆随机抽取了年龄在 18 岁及以上的患者人群，收集 24 小时尿样，并评估匹兹堡睡眠质量指数（PSQI）问卷。将参与者分为 2 组（24 小时尿钾排泄的上下中位数）。睡眠质量差定义为 PSQI 总分≥6。在总人群和按性别分层的人群中，通过多因素逻辑回归分析评估 24 小时尿钾排泄与[24.8mmol/L]睡眠质量之间的关系。
结果
共收集了 1147 例 24 小时尿样，对有完整尿样和 PSQI 数据的参与者（n=727；平均年龄 48.7 岁；女性百分比 62%）进行数据分析。与 24 小时尿钾排泄的上中位数组相比，下中位数组 PSQI 总分明显较高（6 分比 5 分， =.011），且睡眠质量差的发生率较高（51.7%比 42.2%， =.011）。在多因素逻辑回归的完全调整模型中，下中位数组睡眠质量差的可能性增加了 1.50 倍（95%置信区间：1.01-2.24， =.045）。性别特异性分析将这些结果转化为女性，但不适用于男性。
结论
这些结果表明，低钾摄入（表现为尿钾排泄较低）与普通人群的睡眠质量较差有关，尤其是女性。因此，需要进一步研究以阐明增加钾摄入以改善睡眠质量的效果。
引文
Li M, Heizhati M, Wang L, et al. 24-hour urinary potassium excretion is negatively associated with self-reported sleep quality in the general population, independently of sleep-disordered breathing.. 2022;18(11):2589-2596.
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