Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences Changchun, Jilin, 130022, P. R. China.
University of Science and Technology of China Hefei, Anhui, 230026, P. R. China.
Angew Chem Int Ed Engl. 2022 Sep 19;61(38):e202204291. doi: 10.1002/anie.202204291. Epub 2022 Aug 17.
The intelligent nanomachine usually has a control center to carry out self-regulation. Unfortunately, most of the nanomaterials for chemodynamic therapy (CDT) do not have such a control center to sense and process the chemical or biological signals, which greatly weakens the selectivity and efficiency of CDT. To address this problem, here an intelligent nanomachine was constructed with a DNAzyme logic gate as the control center, and metal organic framework as the actuator. The well-designed nanomachine showed an enhanced killing effect on cancer cells but posed no harm to normal cells, acquiring better selectivity than clinical chemotherapy drugs (doxorubicin and cisplatin). To the best of our knowledge, this is the first reported cell-specific CDT by the guidance of DNAzyme logic gate. Our work highlights the great potential of DNAzymes in intelligent response networks, and extends the implementation of nanomachines in precision medicine.
智能纳米机器通常具有执行自我调节的控制中心。遗憾的是，用于化学动力学治疗（CDT）的大多数纳米材料都没有这样的控制中心来感知和处理化学或生物信号，这极大地降低了 CDT 的选择性和效率。为了解决这个问题，这里构建了一个以 DNA zyme 逻辑门为控制中心、以金属有机骨架为执行器的智能纳米机器。精心设计的纳米机器对癌细胞表现出增强的杀伤效果，而对正常细胞没有危害，比临床化疗药物（多柔比星和顺铂）具有更好的选择性。据我们所知，这是首次通过 DNAzyme 逻辑门指导的针对特定细胞的 CDT。我们的工作突出了 DNAzyme 在智能响应网络中的巨大潜力，并扩展了纳米机器在精准医疗中的应用。
