Lothe L, Ivarsson S A, Ekman R, Lindberg T
Department of Pediatrics, University of Lund, Malmö General Hospital, Sweden.
Acta Paediatr Scand. 1990 Apr;79(4):410-6. doi: 10.1111/j.1651-2227.1990.tb11485.x.
Two hundred and nineteen infants, consecutively born, took part in a prospective study of infantile colic from birth to 12 weeks of age. The prevalence of infantile colic in this group was 17.4%. S-motilin was studied in 78 term infants (19 with and 59 without infantile colic) at birth (cord blood), at one day, and at 6 and 12 weeks of age, respectively. Basal motilin levels were raised both in cord blood (p less than 0.01) and in blood from neonates (p less than 0.001) who developed colic as well as in 6 week (p less than 0.05) and in 12-week-old infants with colic (p less than 0.01). Formula-fed infants with colic had higher basal motilin levels than formula-fed controls at 6 and 12 weeks of age (p less than 0.05). Breast-fed infants with colic had higher basal motilin levels than breast-fed controls at 12 weeks of age (p less than 0.05). The raised levels of motilin from the first day of life in infants who develop infantile colic might indicate that the gastrointestinal tract is affected in infants with infantile colic, before any symptoms of colic appear.
219名连续出生的婴儿参与了一项从出生至12周龄的婴儿腹绞痛前瞻性研究。该组婴儿腹绞痛的患病率为17.4%。分别在出生时（脐血）、出生1天、6周和12周龄时，对78名足月儿（19名患有婴儿腹绞痛，59名未患）进行了S-胃动素研究。患腹绞痛的婴儿脐血（p<0.01）、新生儿血液（p<0.001）、6周龄婴儿（p<0.05）和12周龄患腹绞痛婴儿（p<0.01）的基础胃动素水平均升高。在6周和12周龄时，患腹绞痛的配方奶喂养婴儿的基础胃动素水平高于配方奶喂养的对照组（p<0.05）。在12周龄时，患腹绞痛的母乳喂养婴儿的基础胃动素水平高于母乳喂养的对照组（p<0.05）。患婴儿腹绞痛的婴儿从出生第一天起胃动素水平升高，这可能表明在腹绞痛的任何症状出现之前，婴儿腹绞痛患儿的胃肠道就受到了影响。
