First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China; National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China.
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China; National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China.
J Pediatr (Rio J). 2023 Jan-Feb;99(1):11-16. doi: 10.1016/j.jped.2022.06.002. Epub 2022 Jul 30.
In this article, the author aims to discuss and review the relationship between gut microbiota and Tourette syndrome, and whether the change in gut microbiota can affect the severity of Tourette syndrome.
Literature from PubMed, Google Scholar, and China National Knowledge Infrastructure was mainly reviewed. Both original studies and review articles were discussed. The articles were required to be published as of May 2022.
Current studies on the gut microbiome have found that the gut microbiome and brain seem to interact. It is named the brain-gut-axis. The relationship between the brain-gut axis and neurological and psychiatric disorders has been a topic of intense interest. Tourette syndrome is a chronic neurological disease that seriously affects the quality of life of children, and there appears to be an increase in Ruminococcaceae and Bacteroides in the gut of patients with Tourette syndrome. After clinical observation and animal experiments, there appear to be particular gut microbiota changes in Tourette syndrome. It provides a new possible idea for the treatment of Tourette syndrome. Probiotics and fecal microbial transplantation have been tried to treat Tourette syndrome, especially Tourette syndrome which is not sensitive to drugs, and some results have been achieved.
The relationship between gut microbiota and Tourette syndrome and how to alleviate Tourette syndrome by improving gut microbiota are new topics, more in-depth and larger sample size research is still needed.
本文旨在讨论和综述肠道微生物群与妥瑞氏综合征之间的关系，以及肠道微生物群的变化是否会影响妥瑞氏综合征的严重程度。
主要查阅了 PubMed、Google Scholar 和中国知网的文献。讨论了原始研究和综述文章。要求这些文章截至 2022 年 5 月发表。
目前对肠道微生物组的研究发现，肠道微生物组和大脑似乎存在相互作用。它被命名为脑-肠轴。脑肠轴与神经和精神疾病的关系一直是一个热门话题。妥瑞氏综合征是一种慢性神经系统疾病，严重影响儿童的生活质量，患者的肠道中似乎存在更多的罗氏菌科和拟杆菌属。经过临床观察和动物实验，妥瑞氏综合征似乎存在特定的肠道微生物群变化。这为妥瑞氏综合征的治疗提供了一个新的可能思路。益生菌和粪便微生物移植已被尝试用于治疗妥瑞氏综合征，特别是对药物不敏感的妥瑞氏综合征，已取得一些成果。
肠道微生物群与妥瑞氏综合征之间的关系以及如何通过改善肠道微生物群来缓解妥瑞氏综合征是新的课题，仍需要更深入和更大样本量的研究。
