Department of Obstetrics and Gynecology, Faculty of Medicine, Dicle University, Diyarbakir, Turkey.
Eur Rev Med Pharmacol Sci. 2022 Jul;26(14):4991-4996. doi: 10.26355/eurrev_202207_29285.
This study aimed to determine whether or not there was a relationship between complete hydatidiform mole (CHM) and serum Vitamin D level by comparing CHM patients with two control groups and to determine whether or not Vitamin D deficiency is a risk factor for CHM.
This prospective study included 30 patients diagnosed with CHM (case group), 30 patients in the first trimester of a healthy pregnancy (control group), and 30 healthy non-pregnant subjects (control group). A record was made of serum 25-hydroxyvitamin D (25-OH D vitamin) levels, age, body mass index (BMI), gravida, parity, and the number of abortus. The serum 25-OH D vitamin levels were examined in each group and compared between groups.
The 25-OH D vitamin level of all the patients in the study was determined as 11.16±8.64 ng/mL. No significant difference was determined between the groups in respect of 25 OH-D vitamin levels. When comparisons were made between the four subgroups according to the 25-OH-D level, no significant difference was determined between the CHM and control groups. When the patients were separated as obese and non-obese groups, no significant difference was determined between the groups.
Severe deficiency, deficiency, or insufficient levels of serum Vitamin D are not thought to be risk factors for CHM patients.
本研究旨在通过比较完全性葡萄胎（CHM）患者与两个对照组，确定 CHM 与血清维生素 D 水平之间是否存在关系，并确定维生素 D 缺乏是否是 CHM 的危险因素。
本前瞻性研究纳入了 30 例诊断为 CHM 的患者（病例组）、30 例孕早期健康妊娠患者（对照组）和 30 名健康未孕女性（对照组）。记录血清 25-羟维生素 D（25-OH D 维生素）水平、年龄、体重指数（BMI）、孕次、产次和流产次数。检查了每个组的血清 25-OH D 维生素水平，并对组间进行了比较。
研究中所有患者的 25-OH D 维生素水平均为 11.16±8.64ng/ml。各组间 25-OH-D 维生素水平无显著差异。根据 25-OH-D 水平对四个亚组进行比较时，CHM 组与对照组之间无显著差异。当患者分为肥胖和非肥胖组时，组间无显著差异。
严重缺乏、缺乏或不足的血清维生素 D 水平似乎不是 CHM 患者的危险因素。
