Wargotz E S, Werner M
Am J Clin Pathol. 1987 Jun;87(6):773-5. doi: 10.1093/ajcp/87.6.773.
Over a four-month period, methanol was found in the blood of 18 patients among 687 sequential emergency room admissions screened for alcohols by gas chromatography. In the patients with positive results, blood ethanol ranged from 6 to 570 mg/dL (1.3-123.7 mmol/L), blood methanol from 2.3 to 4.0 mg/dL (0.72-1.25 mmol/L). Methanol exposure during preparation of the sampling site or in the course of specimen handling, ingestion of denatured alcohol, as well as methanol production from the metabolism of aspartame are ruled out as causes for these findings. The authors conclude that endogenous methanol production is the probable major cause, while methanol as a fermentation congener may be a contributory minor cause.
在四个月的时间里，在通过气相色谱法对687例连续急诊室入院患者进行酒精筛查时，发现18例患者血液中含有甲醇。在检测结果呈阳性的患者中，血液乙醇含量为6至570mg/dL（1.3 - 123.7mmol/L），血液甲醇含量为2.3至4.0mg/dL（0.72 - 1.25mmol/L）。这些发现排除了采样部位准备过程中或标本处理过程中甲醇暴露、摄入变性酒精以及阿斯巴甜代谢产生甲醇等原因。作者得出结论，内源性甲醇生成可能是主要原因，而甲醇作为发酵副产物可能是次要的促成原因。
