Abramenko Natalia, Mashkin Petr, Volkov Sergey, Olshanskiy Vladimir, Kustov Leonid
N.D. Zelinsky Institute of Organic Chemistry, Leninsky Pr. 47, 119991 Moscow, Russia.
A.N. Severtsov Institute of Problems of Ecology and Evolution, RAS, 119071 Moscow, Russia.
Nanomaterials (Basel). 2021 Apr 8;11(4):944. doi: 10.3390/nano11040944.
The use of different nanoparticles (NPs) is growing every year since discoveries of their unique properties. The wide use of nanomaterials has raised concerns about their safety and possible accumulation in the aquatic environment. Mussels are being considered as one of the most suitable organisms for bioaccumulation monitoring. Within our study, we focused on developing the method that can be applied in field studies of ecotoxicity and can be nondestructive and informative at early times of exposure, while at the same time being based on changes of physiological parameters of fresh water mussels. The changes in the cardiovascular and neural systems of mollusks ( and ) were measured as biomarkers of toxic effects. Different monometallic and bimetallic NPs, silicon NPs with various ligands were applied as test substances. Changes in cardiovascular and neural functions were in good correlation with accumulation tests for all tested NPs.
自从发现不同纳米颗粒（NPs）的独特性质以来，其使用量逐年增加。纳米材料的广泛应用引发了人们对其安全性以及在水生环境中可能积累的担忧。贻贝被认为是生物积累监测最合适的生物之一。在我们的研究中，我们专注于开发一种可应用于生态毒性现场研究的方法，该方法在暴露早期可以是非破坏性且信息丰富的，同时基于淡水贻贝生理参数的变化。测量软体动物心血管和神经系统的变化作为毒性效应的生物标志物。应用不同的单金属和双金属纳米颗粒、带有各种配体的硅纳米颗粒作为测试物质。所有测试纳米颗粒的心血管和神经功能变化与积累测试具有良好的相关性。
