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一种用于全血和血浆中环孢素A的高效液相色谱法的改进提取程序。

An improved extraction procedure for an HPLC method for cyclosporin A in whole blood and plasma.

作者信息

Maguire S, Kyne F, UaConaill D

出版信息

Ann Clin Biochem. 1987 Mar;24 ( Pt 2):161-6. doi: 10.1177/000456328702400206.

DOI:10.1177/000456328702400206
PMID:3592565
Abstract

Cyclosporin A (CyA) was assayed by high performance liquid chromatography (HPLC) following extraction of the whole blood or plasma with diethyl ether and chromatography on a Sep-Pak Silica cartridge. Using carefully chosen volumes and ratios of ethyl acetate and hexane in the eluting sequences on the Sep-Pak, the major interferent present in normal blood and serum was eliminated.

摘要

采用高效液相色谱法（HPLC）测定环孢素A（CyA），方法是先用乙醚提取全血或血浆，然后在Sep-Pak硅胶柱上进行色谱分析。通过在Sep-Pak柱洗脱过程中精心选择乙酸乙酯和己烷的体积及比例，消除了正常血液和血清中存在的主要干扰物。

相似文献

1
An improved extraction procedure for an HPLC method for cyclosporin A in whole blood and plasma.一种用于全血和血浆中环孢素A的高效液相色谱法的改进提取程序。
Ann Clin Biochem. 1987 Mar;24 ( Pt 2):161-6. doi: 10.1177/000456328702400206.
2
Preparation, extraction and high performance liquid chromatography of cyclosporin A from plasma that contains interfering compounds.从含有干扰化合物的血浆中制备、提取环孢素A并进行高效液相色谱分析。
Ann Clin Biochem. 1985 Jul;22 ( Pt 4):402-7. doi: 10.1177/000456328502200413.
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A simple improved method for the measurement of cyclosporin by liquid-liquid extraction of whole blood and isocratic HPLC.一种通过全血液液萃取和等度高效液相色谱法测定环孢素的简单改进方法。
Ann Clin Biochem. 1988 Sep;25 ( Pt 5):510-5. doi: 10.1177/000456328802500506.
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Quantitative determination of cyclosporin A in whole blood and plasma by high performance liquid chromatography.
Res Commun Chem Pathol Pharmacol. 1987 Aug;57(2):261-71.
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High pressure liquid chromatographic determination of cyclosporin A in plasma.
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[A rapid method for the determination of cyclosporin A in blood by high performance liquid chromatography].[一种用高效液相色谱法快速测定血液中环孢素A的方法]
Ann Biol Clin (Paris). 1986;44(5):517-21.
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Determination of cyclosporin A in the serum of kidney transplant patients by rapid-flow fractionation and normal-phase high-performance liquid chromatography.
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New automated high-performance liquid chromatographic analysis of cyclosporin A and G in human serum.人血清中环孢素A和G的新型自动化高效液相色谱分析
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Application of HPLC with a metal-free column to the analysis of cyclosporin in whole blood samples from cardiac transplant patients.使用无金属柱的高效液相色谱法在心脏移植患者全血样本中环孢素分析中的应用。
Res Commun Chem Pathol Pharmacol. 1988 Aug;61(2):261-4.
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High pressure liquid chromatographic determination of cyclosporin-A in human plasma.
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引用本文的文献

1
The management of heart transplant recipients treated with cyclosporine in Ireland: monitoring of cyclosporine concentrations in blood.爱尔兰接受环孢素治疗的心脏移植受者的管理：血液中环孢素浓度的监测。
Ir J Med Sci. 1990 Sep-Dec;159(9-12):272-4. doi: 10.1007/BF02993610.